A bus full of students goes missing during the middle of its morning round. It becomes clear that the bus was hijacked. When it is finally located, it is empty save for one student who explains that the hijackers were two of his classmates who want a large ransom.
A priest from a poor area of town goes missing after a car accident in the city. He needs to be found quickly because he is in need of a liver transplant, and a donor liver has just become available but can't wait for long.
A high school boy goes missing. His family, when interviewed, has no idea where he is and he does not seem like a runaway. When interviewing his friends, the team uncovers information about very wild parties that the students have been having, and suspect the boy's disappearance may have had something to do with an event at one of these parties.
An unknown boy is seen being kidnapped and placed into an SUV in a neighborhood with a large population of undocumented immigrants. Despite no missing person report by the boy's family, the team is able to identify him as a local kid who, for one reason or another, had been desperately trying to get his hands on some money by exchanging cans and selling some of his belongings.
A fire-fighter goes missing, just after a large fire in which one of his close friends, despite having been saved from death, ends up badly injured. Although he had told his wife he was heading home, the fire-fighter disappears on the way.
A man who invests all of his time as a member of the paparazzi disappears after waiting around to get a shot of a professional basketball player. The team discovers that this man may have been trying to change his life for the better in order to help a radical environmental group.
A young criminal defence lawyer working for legal aid goes missing, last seen in the middle of the night apparently running from people shooting after him. A quick bit of research and it is discovered he has recently been diagnosed with paranoid schizophrenia, yet due to the nature of his work, the FBI isn't certain what he is imagining, and what is really wrong.
The FBI investigates the disappearance of Eric Miller, a middle school student who disappeared during a bathroom break. He was only away for about ten minutes, so either he or his suspected kidnappers may have known what would happen. The investigators learn that Eric had low self-esteem and saw himself as part of the loser crowd at school. When his friend tells Agent Johnson about a bullying incident and they also locate a surveillance video from a local arcade showing an older boy pushing him, they realize they may have something other than a kidnapping.
For four years Vivian refused to give up on a dead-end case of a struggling sex addict who went missing. Her perseverance pays off when she receives a break in the case. The hunt for the young woman leads the team on a trail of addiction, abuse, and a strange cult.
A soldier wounded in a firefight in Iraq returns home, only to find his life savings gone, his business closed, and the love of his life with another man. While Jack and Danny travel to Tikrit to investigate what really happened in the firefight, the rest of the team find that the desperate soldier is going to great lengths to get his old life back.
A man disappears after leaving with the day's earnings from the hair salon run by his wife. He had been helping out there since quitting his job after getting into some trouble at work. The investigation discovers that he, his wife, and their 19 year old son had a history of problems and arguments that may have led to the disappearance. Meanwhile, Danny is reluctant to testify in favor of his convict brother at his parole hearing.
A marine biology student is reported missing. The team first suspects the woman's boyfriend, but when new evidence of dead women in different cities points to the boyfriend's identical twin brother, the team struggles to discern which twin is really guilty.
Martin's aunt, a nurse battling cancer, goes to visit a friend but never makes it there. Martin soon learns that his aunt had been assisting terminally ill patients in their suicides. Meanwhile, Jack must deal with his father's medical crisis.
A football coach who is known for his winning team disappears. The team learns that he recently had an attack of conscience, causing him to crack down on the players' academics and ethics. The team's suspect list is filled with suspended players, angry parents, and university administrators.