This game was originally scheduled for North American release on March 22nd 2002, the same day as the film of the same name Blade II (2002). Instead, it was released on September 3rd, 2002, the same day the movie was released on DVD.
This game is not a direct adaptation of Blade II (2002), but is actually a follow up to the movie, taking place six months after the events of the film with Blade and Whistler attempting to prevent the vampires from creating a race of super-vampires even more powerful than the Reapers.