Spider-Man 2 (2004)
- when Spider-Man shows up at Doctor Octavius' failed experiment, Harry assumes he's the reason why it failed.
- Doc Ock thinks he's helping Aunt May by giving her a quick death, rather than a slow one of old age.
- the arms speak to Doctor Octopus. They even regard him as a father, something omitted from the film. The closest it ever gets to that in the movie is when Doc Ock says he hears voices inside his head. They also say things like Spidey interfered in his experiment because he was jealous of Otto's success.
- Uncle Ben appears to Peter frequently, rather than a single dream sequence in the movie.
- when Doc Ock tries to rob the bank and Peter abandons Aunt May, she assumes that the reason he runs away is to call the police, rather than out of cowardice.
- the lift scene initially had Spider-Man sharing it with a whole crowd of people, and not just one person. When Peter tells the man he made the suit himself, the novelization tells us he got it from the brother of The Flying Dutchman, the rival wrestler of Bone-Saw, who Peter fought in the first film. He offered his services after Peter beat up Bone-Saw.
- the police couldn't confirm Uncle Ben's murderer because there were no eyewitnesses. Peter couldn't come forward because of his involvement.
- in the opening scene, when Peter is late for his pizza delivery job because of a disturbance, we learn that the disturbance came from a man on a construction site nearly crushed by a falling girder.
- Mary-Jane met John Jameson at Enriques, the diner MJ worked at in the first film. A trucker pinched her bottom and she dumped a plate of spaghetti in his lap. When Enrique demanded she apologise, she was thinking of caving in when John stepped in. His car battery had died, and he was waiting for a tow-truck. He pretended to be an FBI agent causing Enrique to back down, and MJ quit her job. They started seeing each other not long after.
- Mary-Jane's parents have split up since the first film. Apparently Mr. Watson has changed slightly since the divorce.
- MJ's line "You can't get off if you never got on" sounded suggestive in her mind.
- When Peter goes to see a doctor, it's at the university's student health services department. His name is Dr Wally Davis, and he's more emotional in the book. He even sees a therapist.
- Instead of stealing the money to fund his experiment, Doctor Octopus broke into classified government installations for what he needed. They couldn't risk exposure so they couldn't argue. The tentacles also tapped into an illegal power hookup.
- Peter muses that all the women in his life wind up dangling from a ledge sometime. E.g. Aunt May taken hostage by Doc Ock, Mary-Jane during the Green Goblin's attack on Times Square. It also bothers Peter that he always photographs MJ with other men. In the case of John more so, because he hasn't done half of the heroic things Peter has done, and he's still celebrated as a hero. While Spider-Man is demonized by the press.
- Although Jameson is ecstatic that Spider-Man has given up, in the novelization he's secretly not that happy about it, because Spider-Man sells more editions of the Daily Bugle than any other celebrity, and now that he's gone, sales figures for the Bugle have gone into a tailspin.
- When Peter goes to get his suit back, he was secretly listening to Jameson's eulogy before he took it. Apparently, Jameson had it dry-cleaned so it felt better than ever.
- Apparently when Peter was a young boy, he distrusted his Aunt May after his mother died. But in the reconciliation scene, he begins to wonder if May knows his secret. In that same scene, because he moves a desk with ease, that's what prompts him to try and jump the gap between two buildings, thinking his powers have returned. He doesn't fall on a car though.
- Aunt May begins to blame herself for Uncle Ben's death in the film, but in the novelization, Peter wonders is it because Ben is haunting her as well, especially now he's given up Spider-Man. When he confesses his part in Uncle Ben's death, May tells him to leave instead of just getting up and going to her room in silence as she does in the film.
- Doc Ock tapped Peter's phone lines. That was how he knew he'd find him at a café with Mary-Jane.
- The scene with the burning building was a lot shorter.
- Harry wonders if Quest, Oscorp's biggest rival, hired Spider-Man to discredit his company.
- Betty Brant ensures the bum is paid more for the Spidey suit than Jameson was willing to shell out. In a scene omitted from the film, the night staff at the Bugle say that Jameson wears the suit, striking mock heroic poses when he thought no-one was watching. He even walked onto his desk, sticking paper clips to a lamp like it were webbing. Also, the DA's office want the suit to verify it's the real thing, but Jameson won't hear of it.
- Peter running into a burning building to save a child.
- Peter running across a rooftop before trying (and failing) to shoot his web.
- Peter putting out the trash in aunt May's back yard and speaking to Mary Jane.
- Spider-Man lying incapacitated on the sofa of his enemy.
- POV of Peter Parker looking through his glasses and seeing a blurred image.
- MJ's understudy is playing her part now, and better too MJ suspects. She imagines she'll get replaced, which came to pass in Spider-Man 3 (2007).
- Harry uses a knife to kill Spider-Man, because it isn't traceable like a gun. It belonged to his father. When he unmasks Spider-Man, Harry wondered if Doctor Octopus was trying to fool him by bringing Peter instead. He also hopes that if Doc Ock succeeds with his experiment, the tritium explosion will destroy the half of the city that he's in.
- Mary-Jane is shocked Harry would want to kill Spider-Man.
- Doc Ock bound Spider-Man with wire from the train yard. When he brings him to Harry Osborn's, he cracked open the safe himself.
- In the novelization, Doc Ock blamed Spidey for Rosie's death.
- Doc Ock doesn't throw any passengers at Spider-Man during the fight on top of the train.
- The reason why the railway runs out of track is because the city was building an overpass above the train yard, but the money ran out and so it was never finished. Also, the engineer Donald O'Shea was about to retire. The way the scene played out in the book, Spidey uncoupled the passenger cart from the engine. He's not pulled as tight and at the end of it, one of the passengers removes his mask thinking they can cash in on him, much to the anger of the driver. One of the passengers had been one of the protesters who pelted the Green Goblin back in the first Spider-Man (2002) film. Spider-Man never regained consciousness throughout all this.