Tobey Hollins is caught by the Miami Police Departement and is sent to prison for murder. Horatio has some doubts about Tobey's guilt, since some evidences clearly identify some one else as the murderer. Horatio and his team now try everything to disprove Tobey's guilt.
Pool employee Armando Diaz's bloodily battered corpse is found in Craig Seaborn's 5-star hotel Graciana's gardens. He was killed in the penthouse, where three wives had a 'husbands nor sex' weekend. Beth Jacobson admits she had sex with him, but when he called her too unattractive to get hard a fight ensued, so she struck him with a towel bar, thrice. He also had safe sex with Felicia Hardy, who claims she didn't realize he was badly wounded when passing out after hitting his head against the bed. Wolfe follows a third blood trail, to the staircase and more suspects. ...
Henry Darius, a man who killed several women in New York, claims that he also killed a woman in Miami and offers to show them where he buried her. The plane transporting him suddenly has to make an emergency landing and Dairus escapes. He kills some people to get their car. Horatio learns that the plane was sabotaged and he thinks Darius had a hand in it. Horatio sends for New York Detective Mac Taylor who was the one who caught Darius. Horatio decides to look at the woman's disappearance again and discovers that the husband didn't tell him some things that could have...
Ryan Wolfe, with a nail knocked next to his eye, is being carried to hospital by Delko. There, Horatio remembers how the day started, with the discovery of a murdered woman who was attacked by someone with a nails gun.
During an early morning trip to the bank, Delko ends up witnessing a robbery and fatally shooting one of the suspects. As the investigation progresses, Wolfe realizes that the robbers are trying to replicate a violent video game.
When a drug dealer is gunned down in his home, Horatio and the team must determine who, out of three suspects, committed the crime. Meanwhile, Delko faces a serious threat to his career, and Calleigh makes a decision about hers.
New technology on DNA testing reveals that a man convicted of a rape six years back is innocent and he is promptly release. Now a free man, he is eager on pressing charges against the department and the crime lab for his false conviction. Meanwhile, Horatio and his team reopen the case in hope to catch the real rapist. In the morgue, Alexx examines the body of a young woman who died from infections caused by a piece of cloth left inside her after an operation. She is intent on finding the surgeon responsible for this untimely death.
The owner of a club is found hanging from a bridge, with two shots in his eyes and a joker card in his pocket. At first it looks like a Mafia work, but the suspects list drastically changes when the CSI team discovers that the murder is described in the script of an upcoming movie.
A trip to the beach for Eric Delko turns sour when a body is uncovered beneath the sand. The man was killed elsewhere and dumped here. Elsewhere, Horatio is certain that his old enemy from New York is back when two murders occur in Miami. He immediately contacts Jennifer Wilson whose parents were killed by the same murderer, Walter Resden, many years back when she was still a little girl.