(at around 15 mins) When Officer Thomas Burke sees the pile-up and collisions, he runs to his car and radios in, "This is Unit 13, requesting medical assistance and back-up for a major traffic accident." It hardly needs to be pointed out that 13 is considered an unlucky number.
(at around 1 min) In the opening sequence Kimberly's car keys are shown. Her key chain is an evil eye bead. The evil eye, in middle eastern cultures is a talisman that wards off evil spirits and negative energy, and by doing so protects the owner. There are also other superstitions regarding the evil eye, the main one states that the evil eye can not be bought for oneself, it has to be gifted to them.
The police officer radios in an accident at mile marker 180 (the accident where the news van eventually blows up). Also when Kim is standing next to her SUV at the exit ramp just before the officer pulls her out of the way of a truck, she sees a road work sign "next 180 feet". These are references to flight 180 in the first movie.
(at around 31 mins) In the movie, Ali Larter's character is at the Stonybrook Mental Institution. However, there is a real town named Stony Brook on Long Island that is home to a university and medical hospital that bears its name. The map displayed on mapquest in the movie is the actual location.
In the original Final Destination (2000), many characters are named after black-and-white horror film stars or directors. In this movie, Kimberly Corman is named for famous horror director Roger Corman.
(at around 31 mins) Filmmakers say that the man hanging on the jail bars when Kimberly walks into the insane asylum is put there to pay homage to Chief Bromden (Will Sampson) in One Flew Over the Cuckoo's Nest (1975).
(at around 32 mins) When the principal character enters the sanitarium the words "Get them off me" can be heard coming from one of the cells. This is a reference to a lunatic (also imprisoned in an asylum) in Hellbound: Hellraiser II (1988), who carves himself up with a straight-razor because he suffers from a delusion that he is covered with bugs.
(at around 41 mins) When Nora is reading "Reader's Digest" in the dentist's waiting room waiting for Tim to be done, the camera pans in on her showing only the word "Deader", another premonition of things to come.
(at around 1h 9 mins) The TV news van at the farm has the call letters WWED which is registered to a classical music station in Virginia meaning the crew picked those letters on purpose. They stand for "When Will Everyone Die."
The trivia items below may give away important plot points.
at around 27 mins) Originally, Devon Sawa was to reprise his role of Alex Browning in this film, but a dispute concerning his contract with New Line Cinema could not be settled. In this film, it is implied by a newspaper clipping that his character Alex was killed off by a falling brick to the head.
at around 23 mins) When Evan is examining his new ring, the horseshoe shape is pointing downwards, which is considered bad luck. It is immediately after this that the chain of events begin that lead towards his death.
at around 22 mins) When Evan is in his kitchen before his death, he leans over to get something out of his fridge and you can see the letter magnets "HEY E" on the side of the fridge. When Evan puts the leftover Chinese food container on the counter, the "H" magnet falls off and lands in the container. The letters left spell out the word "EYE," which foreshadows that Evan will die when he is impaled through the eye with a fire escape ladder.
at around 29 mins) When Nora tucks Tim in at night, dimming the lights, his face is illuminated with a skull outline, and can be better seen when the scene dissolves into the next, foreshadowing his death.
at around 47 mins) The mortician says that only new life can break death's cycle, a life that wasn't meant to be. This is already proven false as Alex was technically dead after he was electrocuted in the first film yet he and Clear still die.
at around 1h 18 mins) In Final Destination 2 Clear Rivers is killed by a fire in the hospital. In the first film Alex's premonition is that she is burnt on the plane, the exact same way she burns in real life on the second film.
This is the only film in the series with survivors. The first film left two characters still alive at the end, Alex Browning and Clear Rivers, however they had not evaded deaths wrath, with Alex dying between the first and second films and Clear dying in this film. Kimberly and Officer Burke are the only characters in the entire series to have successfully escaped Death's wrath, with the third, fourth and fifth films in the series all ending with the remaining characters killed in a disaster similar to the first disaster they escaped.