The first Scooby-Doo series not produced by Hanna-Barbera Productions, even though the show is still copyrighted by them; Warner Bros. Animation (the unit responsible for Tiny Toon Adventures (1990) and Animaniacs (1993) and many classic Looney Tunes shorts, among many others) did the production work, having assumed production on the Scooby-Doo franchise since 1998 with "Scooby-Doo on Zombie Island." Warner Bros. Animation had absorbed Hanna-Barbera Productions in 2001 following the death of William Hanna.
The first regular series to use all of the original Scooby characters since _"Scooby and Scrappy-Doo" (1979)_. The New Scooby-Doo Mysteries (1984) featured Velma and Freddy in a few episodes, but most only feature Scooby-Doo, Scrappy-Doo, Shaggy, and Daphne.
The first time since 1995 that Casey Kasem has done the voice of Shaggy. You will also notice that Shaggy is a strict vegetarian in this series. See the trivia for _"Scooby-Doo, Where Are You!" (1969)_.
The first Scooby-Doo show to abandon many of the classic Hanna-Barbera sound effects, which were a trademark of the previous shows that Hanna-Barbera Productions produced. Although a small portion of the Hanna-Barbera library is still used, new Foley effects were recorded and created exclusively for the series to make it sound more "realistic" and "updated," compared to the older, more "cartoony" shows.
Scott Innes did not reprise his role as Scooby-Doo for the series, so they were thinking of replacing Innes with Marty Grabstein, but Grabstein was too busy voicing his other cartoon dog character "Courage the Cowardly Dog", so the role for Scooby went to Frank Welker.