Frylock attempts to contact extraterrestrial life forms, and succeeds. Frylock is transported aboard an alien spacecraft in space. Shake visits the spacecraft also. The two aliens are bumbling fools, who say that their aim is world domination. Meanwhile, back on Earth, Carl had paid Shake to mow his grass, but Shake subbed the job out to Meatwad. Meatwad burns Carl's lawn. When Shake returns from space, he must face his angry neighbor Carl.
The enormous horrible mess that Master Shake has made in the kitchen is drawing flies and beginning to rot. It becomes so fetid that it gives birth to a sentient mould growth, who Meatwad names Ol' Drippy. The large talking fungus turns out to a very gracious and agreeable roommate, way more so than Shake, and the teens are tempted to kick out Shake and replace him with Ol' Drippy.
Meatwad listens to rapper MC Pee Pants' song "I Want Candy" day and night. The constant noise annoys Master Shake, who threatens a violent retribution. The music also annoys their neighbor Carl. Both Carl and Meatwad have developed a serious sweet tooth since Meatwad started listening to MC Pee Pants. The vigilant Frylock is disturbed by some of MC Pee Pants' lyrics, which he says foretell of a violent plot. Meanwhile, Carl and Meatwad depart for an address which is mentioned in one of MC Pee Pants' songs.
Master Shake receives a phone call from aliens, who he believes to be Hollywood casting directors offering him a part in a movie. They lure him to their spaceship, where he is whisked into space. The aliens send a replicant to live with Meatwad and Frylock. The replicant only vaguely resembles Shake, so Frylock sees through the ruse. Undaunted, the aliens give their replicant orders via a videophone. The replicant seems woefully inadequate to the aliens' task of world domination.
Master Shake sells Meatwad to a circus, but Frylock and Meatwad thinks Meatwad is going to computer camp. The man who bought Meatwad turns out to be the prince of Jupiter and he wants to take over the world.
Frylock and Meatwad discover a mummy under their house. The mummy is almost immobile, but he still can speak. Carl, unfazed by the mummy discovery, explains that the house's previous tenants had strange ways. The mummy makes very difficult demands, but Frylock, wary of the possibility of a mummy's curse, tries to satisfy each and every one.
When Meatwad learns through observation that he has no brain, his attitude changes; he becomes listless, bitter, and despairing. Frylock, hoping to cheer Meatwad up, searches for the means to acquire a brain. Carl obliges - with a fresh human brain obtained care of his friend, Terry. The effects of the brain transplant are quite dramatic on Meatwad; he begins to read more frequently, he enlarges considerably, and he even goes so far as to create an "anti-matter eliminator."
Master Shake and Meatwad play around with an Internet search engine on Frylock's computer and accidentally invoke the Wwwyzzerdd, a cyber-deity who floods the Aqua Teens' house with real-life pop-up ads. Shake's gullibility does little to help with the situation.
The episode starts with Master Shake going on a rampage, looking for his "stolen PDA." He leads the Aqua Teens on a wild goose chase looking for his PDA, including "hunting alien footprints in the Adirondacks," and "Romulox in the Trenton Tar Pits."
It's Christmas time in the neighborhood, and the members of the Aqua Teen Hunger Force are in a holiday mood. Frylock is trying to ensure that Meatwad gets a gift that he wants. Meatwad, chronically short on cash, plans to decorate the house and make gifts for his friends. Meanwhile, Master Shake and Carl have used Frylock's computer to purchase a mail-order bride from Chechnya. The woman arrives, but when she meets her fiancees, she barricades herself inside Carl's house.