The original script had Kelly Robinson as a basketball player, but due to Eddie Murphy's stature it was decided to change him to a boxer. The interchange about the Harlem Globetrotters remained, however.
The characters from the TV series are reversed in this film version. In the original TV series, Kelly Robinson (not Alexander Scott) was the white guy and the athlete, while Alexander Scott was the black guy and the non-athlete. In both cases, however, the Bill Cosby /Eddie Murphy character was a less experienced spy than the Robert Culp /Owen Wilson character.
There is a scene where the agents are sneaking behind the bad guys using a tracking device. They start in the hotel and get into the bath house. In reality, the hotel and the bath are in the same building.