Several of the cast and crew were covered in poison ivy throughout the filming of the movie, this was due to the chairs being placed in what was first thought to be a group of weeds only later to be discovered as a patch of the rash causing plants.
When the four are running from the cabin after awakening the mountain men, Desmond Harrington broke his right ankle after landing on the opposite side of a log. This made it very difficult to shoot some of the scenes after his left leg is "shot" and he has to limp on his right leg.
Years earlier before Wrong Turn (2003) was made cult horror director John Carpenter and another writer James Nichols wrote unproduced horror thriller script titled Prey which had plot that was very similar to both Wrong Turn (2003) and The Hills Have Eyes 2 (2007). Carpenter described his Prey script as mix of Deliverance (1972) and The Texas Chain Saw Massacre (1974). The main characters of the script were three young women who go on a trip through the woods in order to get to some mountain but then they are captured by inbred family living in the woods, and the father of the family wants to use the women as breeders. At one point in the story of the script the last surviving woman escapes from the inbred family and just like in this movie the family members start hunting after her through the woods but end up being killed by her during the hunt and father of the family getting captured and put in jail.
Despite only being credited for his producing, Make-up master Stan Winston was pivotal in the key design of the Mountain Men, in particular now post-modern horror icon Three-Finger. This marks the second last major horror film he has been involved before his death in 2008 at age 62 and the third slasher horror film he had been involved in following uncredited work in Friday The 13th Part II and III, the latter of which he had been a core designer on the original hockey mask of also horror icon Jason Voorhees and the respective mongoloid appearence of Jason for those two parts.
Into pre-production when McElroy had decided to drop the idea of Chris Flynn's victim company being late twenties adults in order to attract the Teenage Slasher Horror crowd he set Jesse Burlingame, her best friend Carly and other friends to the age of 19, setting them as college teenagers still in their freshmen year of higher education. The decision came about when referring to the scripted opening of the film in which rock climbing college teenage couple Halley and Rich are subsequently killed by the Mountain Men.