James Brolin was originally approached for the role of Bernie but turned it down. When director Jay Roach went to approach Dustin Hoffman for the role, Hoffman was talking non-stop and even out of the point which made him the instant choice for Bernie.
The close-up of Bernie Focker's license plate, as he and Greg are driving away, reveals the letters TMI, a subtle reference to Bernie's propensity for overly detailed explanations and descriptions of personal information. TMI is the literary abbreviation for Too Much Information.
During production, the proposed title of "Meet the Fockers" was thought by the studio to be too vulgar. The spelling was briefly changed to "Meet the Fokkers", but that would have upset the franchise's continuity, so it was changed back.