Five characters from Degrassi Junior High/Degrassi High have made regular appearances on the show: Snake (now Mr. Simpson), Spike, Joey, Caitlin and Mr. Raditch. Others have made guest appearances or cameos when circumstances have called for it.
In Canada, nine episodes have viewer discretions on them, "Time Stands Still (Part 2)" (school-shooting), "Shout (Parts 1 & 2)" (rape), "Secret (Parts 1 & 2)" (oral sex and gonorrhea), "Don't You Want Me (Parts 1 & 2)" (stripping), and "Jane Says (Parts 1 and 2)" (child molestation). However, in the United States, only "Shout" came with a viewer discretion warning.
In the episode "Take My Breath Away" (2x10), Craig and Manny go on their first date. Later while Craig is talking to Jimmy and Spinner, he says Manny kept reminding him of his little sister, Angie. In fact, Cassie Steele (Manny) and Craig's little sister Angie (Alex Steele) are sisters in real life.
Emma, Manny, and Liberty have all been nude in public. Emma took her Purple Dragon dress off in front of a crowd. Manny took her dress off for Peter's video camera when intoxicated. And Liberty has streaked after getting drunk.
As of 2012, four characters have had the Degrassi logo on their backs at the end of the opening theme. The first was Marco Del Rossi from seasons 3 through 7. Second was Jane Vaughn from season 8 to 9. Alli Bhandari starting season 10, Drew Torres in season 11, and lastly, Clare Edwards in season 12.
During season two, Terri MacGregor becomes a successful plus size model. In real life, the actress who plays Terri, Christina Schmidt, left the show to become a real life plus size model. She is represented by B&M Models in Toronto and has been featured in Italian Vogue, as well as ads for Torrid, MXM, and Nygard.
Four characters have made attempts to kill themselves during the show. Ellie almost drowned herself (she can't swim) in "Degrassi Goes Hollywood" but is saved by Craig. Craig himself jumps in front of a train in season 2 but is saved by Sean. J.T. Yorke overdoses on drugs due to his stress of losing Liberty, his job, Toby, and his family. He is rushed to the hospital on time though. Darcy slits her wrist in season 7 after she was raped but is found in time by Manny in the showers.