On his first day at the Sacred Heart Hospital new Intern J.D realizes that being a doctor is a whole lot different and harder than he actually thought. At the end he finds out that people are not always what they seem to be at first, for example Dr Kelso who did act nice is actually a complete Jerk and mean Dr Cox is actually a good guy.
J.D, convinced that one of his patients is sick as a result of misconduct on Turk's behalf, questions not only his (Turk's) abilities as a surgeon but their friendship also. Elliot feels disrespected by Dr. Kelso after he refers to her as 'sweetheart' during rounds. In the meantime, J.D. misses his chance to kiss Elliot after being interrupted by Dr. Cox, leaving him 48 hours to get the kiss, in the fear that they will end up as just friends. Will he make it in time?
While J.D. continues to misinterpret Dr. Cox, Elliot discovers parts of her body may have magical healing properties. Turk tries to woo Carla but she may not be as impressed with his gift as he thinks she should be.
J.D. is assigned to look after a difficult, but beautiful, member of Sacred Heart's Board. Her ties to the hospital may not be the only thing that makes it difficult to treat her. Meanwhile Carla freaks out after her mother in injured when she left her to spend the night with Turk.
It's Thanksgiving at Sacred Heart and J.D. is diagnosed with appendicitis. Dr. Cox tries to gain the attention of his former mentor, and former chief of medicine, Dr. Benson. Meanwhile, Elliot tries to become a 'warmer' doctor towards her patients.