Lucy ignores Dr. Cox's advice not to get emotionally invested in her patients, and learns her lesson the hard way. Meanwhile, Denise is hurt when she becomes emotionally involved with an intern who is only in it for the sex.
JD spends his final day as a teacher trying to find out who gave him a negative review, Lucy looks for a "blood buddy," and Dr. Cox tries to convince Denise that Drew has taken charge of their relationship.
J.D. and Elliot's sex life disappears as they get closer to the birth of their child, Dr. Cox refuses to sign his will after a patient dies, and Lucy is terrified of cutting a familiar cadaver for a group exam.
Dr. Cox tries to find out which member of Lucy's study group cheated on a test, Drew gets in trouble when he tells Denise he loves her and then makes the situation worse, and a patient irrationally chooses surgery over treatment.
Cole is depressed when nobody but Lucy shows up for his melanoma procedure, Dr. Kelso loses some of personal independence after some tests, and Drew discovers that Dr. Mahoney has the same personality as Dr. Cox.