Scarlett Pomers (Kyra) went into treatment for an eating disorder and therefore only appears in two episodes of Season 5. When she returned in Season 6, jokes were made about Kyra's absence; such as Reba asking "Where have you been?" to which Kyra replied, "I went to get something to eat."
The character of Reba was originally going to have the name "Sally" but Reba McEntire decided that because she had such a loyal fanbase from her singing career, naming the character Reba would help her fans connect to the show.
JoAnna Garcia Swisher (Cheyenne) and Steve Howey (Van) appeared in a music video for Reba and Kenny Chesney's song, Every Other Weekend together. The two were unnamed but played a divorced couple that share custody of their children and exchange them "every other weekend". Despite the fact that they are divorced, both characters state that they still love each other but are unable to tell each other in front of their children because of the questions that would arise.
After the fifth season, the show was picked up by The CW because UPN merged with The WB to form The CW. However, the show was not picked for a full 22 episode order. Season 6 was given at the last minute for a mid-season replacement if any shows got cancelled or were put on hiatus.
Had three different opening credit sequences, with same musical song in its first three seasons. A new opening credits' photography was done seasonally the first two seasons. Seasons four, five and six were the same as season three.