Clint helps a blind man by means of a corneal transplant, but his wife wonders if the world he sees will come up to his expectations. Dr. Crane is dismayed by the gratitude of a mobster whose life he saved.
After Dr. Crane tells a patient she needs an operation that will leave her unable to have children, Clint violates Crane's orders and suggests an experimental procedure. Raul befriends a troubled homeless girl.
While treating a teenage girl for a mysterious illness, Clint helps her heal a rift with her father. The unexpected arrival of Nate's ne'er-do-well brother causes problems between Nate and Beverly. Dr. Derek can't get rid of the hiccups.
Clint, Nate and Beverly try to arrange a memorable Christmas for Raul, who misses his mother. Nancy is annoyed when the clinic's gift exchange requires her to get something for Dr. Crane. Clint clashes with Dr. Crane over pro bono medical care for sidewalk Santas. Dr. Derek's wife goes into labour.
A couple comes to Clint seeking infertility treatments but Clint's diagnosis and medical advice surprise them. A rival clinic challenges the Westbury Clinic to a bowling match for their annual charity competition and our gang thinks they finally have a chance to win until Tippy joins the team. Nate and Beverly counsel an engaged couple and end up learning a thing or two about their own marriage.
Nate tries to help a workaholic who is to busy to worry about his own health or to spend time with his family. When money disappears from a crime scene, Nate and his partner are investigated by Internal Affairs.
Clint tries to convince a college basketball coach that his son, a star player, may have a serious heart defect. A woman sues Clint for malpractice, claiming that his treatment robbed her of her psychic powers. Raul starts following Clint and Nate around for a school assignment. Nate tries to determine why Jelly Bean confessed to a crime he didn't commit.
Clint tries to help a man who refuses to publicize his need for a lung transplant because he is afraid that a secret from his past will come out. When Raul has trouble with a bully, he is rescued by a girl.