Originally intended to be a documentary entitled "The Cook" about Methamphetamine cooks (makers of the drug) and its dealers and abusers. Instead, the project became a screenplay based on three days in the life of the film's creator/writer/co-producer, Will De Los Santos as he drove a methamphetamine cook around Eugene, Oregon, for three days in the winter of 1995.
One of the characters is watching a video by Norwegian black metal band Satyricon. The song is called "Mother North". The group agreed to Jonas Åkerlund using the video upon condition that he direct their next video clip "Fuel for Hatred". He shot the video in 2003.
Madonna was originally cast as The Neighbor, then porn star then Ginger Lynn. The role eventually went to Debbie Harry. Madonna backed out because of scheduling conflicts with her 2001 North American tour. Lynn backed out for unknown reasons, and was replaced by Harry.