48 Hours examines the abduction and disappearance of University of Virginia student Hannah Graham and looks at its connections to two other disappearances in Virginia: Morgan Harrington and Alexis Murphy. Ultimately, police connect the abduction to a former Liberty Football player Jesse Matthew.
48 Hours examines the arrest of Jesse Matthew the chief suspect in the disappearance of University of Virginia student Hannah Graham. Hannah's body is later discovered in a search of an abandoned property while Matthew is indicted for an abduction and rape of another woman in 2005. Matthew enters an Alford Plea and is later charged with the murders of Hannah Graham and Morgan Harrington.
48 Hours goes to Syracuse, New York, to examine the death of Leslie Neulander. Initially her death is ruled accidental, but forensic specialists argue that she did not die as the result of a slip in the shower. Ultimately Leslie's husband Robert a respected doctor is found to be guilty of the murder despite the testimony of his daughter.
48 Hours goes to California to examines the case of Andra and Brad Sachs who where shot to death in their San Juan Capistrano mansion in February 2014. Initially, the crime is believe to be the result of a business deal gone bad. Several months later, however, police arrest their son Ashton for the murder and say that his motive was jealousy. He also stands accused of shooting and paralyzing his younger brother.
48 Hours goes to Las Vegas to examine the murder of casino cocktail waitress Shauna Tiaffay who was beaten to death in her living room with a hammer. Police investigators eventually discover that she was killed by a Noel Stevens in a hit that was arranged by her estranged firefighter husband George Tiaffay.
48 Hours goes to North Carolina to examine the disappearance and murder of Fort Bragg Army Specialist. Kelli Bordeaux in April 2013. Police with the help of a private investigator eventually determine that the murderer is convicted sex offender Nicholas Holbert who Kelli had recently befriended at a local bar.
48 Hours examine the 2007 murder of Patrick Duffey by his wife Linda Duffey Gwozdz in Los Angeles. Linda admits to having shot her husband, but claims it was an accident that occurred as they were recreating a scene from a cartoon. Although her initial trial lead to a hung jury, her second trial finds her guilty due mostly to the testimony of firearms experts.
48 Hours offers a special report on the recent ISIS terrorist attacks in Paris, France. It goes to Paris for a live report and talks to witnesses to the attacks. It also talks to counter-terrorism officials for analysis, reports on the conflict in Syria, and considers the impact of the attacks on the U.S. presidential race.
48 Hours re-examines and updates the case of Harold Henthorn whose wives Lynn and Toni died 17 years apart in what were supposedly freak accidents. Police investigators, however, believe that Harold murdered them. Eventually, Harold is arrested and convicted of first-degree murder.
48 Hours examines the 2002 death of Nancy Sonnenfeld in Denver, Colorado. Her husband Kurt, a former videographer for FEMA, claimed that it was suicide and moved to Argentina. Police issued a warrant for his arrest in 2003. Sonnenfeld is currently fighting extradition claiming that the U.S. is trying to silence him for something he discovered about 9/11.
48 Hours looks at the 1990 murders of Richard and Nancy Bishop Langert by David Biro in Chicago, Illinois. It examines how Nancy's sister Jeanne through her Christian faith has learned to cope with the deaths and has even forgiven her sister's murderer.
48 Hours examines the case of Dorothy Lee who kidnapped her daughter in the middle of a bitter divorce with her then-husband Harris Todd. She eluded the FBI for two decades eventually settling in Australia. Recently arrested she tells her side of the story and her daughter reflects on the past she never knew about.
48 Hours updates its story on the 2014 murder of heiress Nancy Pfister in Aspen, Colorado. Trey Styler was convicted after his confession to the crime. He has since committed suicide while in prison. His wife has changed her name and moved to a different state.
48 Hours offers a second update on their story on the 1996 murder of Kent Leppink near Hope, Alaska. Police originally convicted Mechele Hughes and John Carlin of the crime, but after Carlin's death in jail Mechele was released on bail. Prosecutors have chosen to not give her a retrial due to the now weakened case against her. She lives in Washingston state though she is separated from her husband.
48 Hours talks to the survivor of a brutal December 1990 gang rape in California. She speaks about her abduction, assault, and eventual release by her to attackers. Eighteen years later a DNA match eventually links actor and former MMA fighter Joe Son to the attack. Police also arrest one of Son's former associates Santiago Gaitan who pleads guilty to the crime.
48 Hours updates the case of millionaire Robert Durst who was recently the subject of the HBO True Crime documentary. Durst is suspected of involvement in the disappearance of his wife and was once charged for the murder and dismemberment of a neighbor. He is now facing trail in Los Angeles for the 2000 murder of Susan Berman.
48 Hours goes to Kaufman, Texas, to look at the January 2013 murder of Assistant District Attorney Mark Hasse and the March 2013 murders of District Attorney Mike McLelland and his wife Cynthia. Police later arrest former attorney and justice of the peace Eric Williams who was once prosecuted by the two victims.
48 Hours goes to Quincy, Illinois, to examine the case of former prosecutor and University of Illinois football star Curtis Lovelace who was arrested in August 2014 of murdering his wife Cory who died on Valentine's Day in 2006. Prosecutors claim she was suffocated by her husband while the defense claims she died due to an enlarged liver and bulimia. The case turns on what the Lovelace children remember of the Valentine morning. Ultimately, the case ends in a hung jury and Lovelace is released.