Scriptwriter Charlie Kaufman felt dissatisfied with the way George Clooney treated his script. He commented: "I spent a lot of time working on the script, but Clooney wasn't interested in the things I was interested in. I've moved on, and I've no animosity towards him, but its a film I don't really relate to." Clooney acknowledged he made changes, because there were 'funky scenes' that never would have got the greenlight for a studio film.
The film was spoofed in a brief article in The Onion entitled "Movie Marketed as Six Different Genres" ("a romantic comedy, a spy thriller, a Hollywood satire, a straightforward biopic... a strange, Being John Malkovich (1999)-esque mind-bender," and a chick flick).
A tour guide says that her favorite television show stars Rosemary Clooney, aunt of director George Clooney. G. Clooney also includes R. Clooney in the movie by playing her recording of "There's No Business Like Show Business" over the end credits.
After his training, Sam Rockwell's character says goodbye to "Jack" and "Lee." Considering popular conspiracy theories regarding the Kennedy Assassination, this is clearly a tongue-in-cheek reference to Jack Ruby and Lee Harvey Oswald.