After Larry's quest to find the perfect excuse for missing a pair of parties backfires on him big time, he gets in a tense, heated fight with Cheryl. So to make up for it, he agrees to take in the Black Family, who lost their home in Hurricane Edna. But can the Blacks deal with Larry's total recklessness and lack of respect, not to mention his poorly planned pastry selection?
Larry decides to be nice for a change and actually donate money to a worthy cause. But when he's revealed to be the anonymous donor for the hospital wing, Larry goes ballistic. He then accuses a dry cleaner of giving his jersey to someone else, and goes off in search of it. Meanwhile, Larry, Jeff, and the Blacks get their reputation stained.
A sweaty $50 bill, a sample abuser, a roadside memorial, and a private school superintendent are all things that intimidate Larry while he tries to help Marty Funkhauser cope with the sudden death of his mother in a freak accident.
Questions about Larry's bathroom habits become concern when Larry gets Richard Lewis' girlfriend a job at a place across the hall from his office. Meanwhile an incident involving a waiter and some take-out food threatens Jeff's dog.
Larry's birthday gift to Ted Danson - a coffee table book called "Mondo Freaks" gets him in trouble with everyone he shows the book to, which includes Ted, the limo driver, tennis star John McEnroe, a group of random mourners, and Paul McCartney's ex-wife Heather Mills.
A faulty toaster makes life difficult for Loretta and Leon. Larry repeatedly offends a hearing impaired girl about the small dog she keeps with her. Larry and Leon get their phones mixed up, and Larry traumatizes the entire audience at Sammy's middle school production of Grease when he invites Jeff's exterminator to watch the show.
Cheryl is finally tired of Larry being Larry after her plane encounters severe turbulence and Larry seems more concerned about a malfunctioning TV device. After Cheryl announces that she's leaving Larry, the incident quickly splits up Larry's friends, who now have to break the news to Larry as to whose side they are taking.
Larry goes to the hospital to see his new girlfriend, an orthopedist. While in the bathroom, Larry overhears one end of a very angry, horribly offensive cell phone conversation. But repeating what the man said offends another doctor - the same one who is about to perform Jeff's operation. But it only results in Jeff's head getting shaved, who now has to deal with being bald. Larry has to give testimony as Jeff prepares to sue the hospital.
Larry devises an overly elaborate plan to win back Cheryl. He does so by trying to get on her therapist's good side. Meanwhile, Larry accuses Marty Funkhauser of taking charity money under false pretenses.
The Blacks learn some good news: they get to go home. As Larry says goodbye, he once again offends the wrong person, who takes his revenge on Larry by spreading a nasty rumor involving him and a gerbil. But thankfully Jeff's daughter's bat mitzvahs is coming up, and that provides Larry with the perfect, public opportunity to clear up that nasty rumor, as well as one more chance to patch things up with Cheryl.