In the Season Eight finale, Larry accuses NY neighbor Michael J. Fox of harassment; Jeff takes a bullet for Susie; and Larry is scolded for giving an inappropriate birthday gift to Jennifer's son, Greg.
Wanda Sykes thinks Larry purposefully adopted a dog she deems "racist", Larry falls off his pedestal as a friend of the lesbian community, and Larry hires a private investigator to uncover some information about his past.
Larry learns that Richard Lewis is bedridden and needs a kidney transplant. Larry and Jeff both turn up as positive matches for Lewis, but neither one are willing to give up their precious organs that easily.
A sex offender (Rob Corddry) moves into the neighborhood, and becomes friends with Larry. Larry also suspects that Dr. Mark is stealing his newspaper, after his neighbor Ethel claims she saw him take it. Tension mounts when all of these people are guests at Larry's Passover Seder.
Larry's quest to get Richard Lewis a kidney takes a turn when Larry learns about the head of the kidney consortium. After befriending the guy, Larry invites him and his daughter on a ski trip. Like everything Larry does, the trip ends as badly as it started.
In the 5th season finale, Larry discovers who his real parents are, and flies to Arizona to meet them. After a life-changing religious revelation, Larry decides to give Richard Lewis his kidney. Will Larry survive the operation... or is it the end?