Executive producers Ron Cowen and Daniel Lipman said they encountered an extreme amount of homophobia from other Hollywood industry professionals, during the pre-production and casting process for this television series.
Peter Paige (Emmet) auditioned for the role of Ted. After he auditioned he politely asked to read for the role of Emmet. The casting directors were so stunned by his performance that they asked him which role he would rather play when he came back to audition for the producers.
In the pilot episode, Michael goes through the back room of Babylon looking for Brian. On his way, He sees another friend (who's having sex) and says, "Hey, Todd! How's it going?" Todd looks at him and says, "Fine!" A different character asks Todd the same thing in the first episode of the first, second, fourth, and fifth seasons.
According to creators Ron Cowen and Daniel Lipman, when shooting the fourth episode, in the scene where Ted wakes up from the coma to find Brian fucking the nurse, the actor playing the nurse refused to do much nudity or an explicit sex scene. From that moment on, Cowen and Lipman were very clear when casting guest actors -especially for the character's one-night stands- that nudity and graphic sex scenes would be required.
The producers decided to pursue the project after reading an article in the Los Angeles Times that critically praised the UK version and said that any American attempt at a show of this nature would be a complete disaster.
Several times throughout the show, Emmett Honeycutt is identified as originally being from Hazlehurst, Mississippi, a real town of about 4500 on the outskirts of Jackson. This may have been the writers' tribute to one of the most famous people to come from Hazlehurst: John Epperson, an actor and singer arguably best-known for his drag persona Lypsinka.
In the final two seasons of the show the opening was changed. Within this opening there are three black t-shirts that are featured. they say (in order) "God made me gay" (worn by a man), "I [heart] my gay son" (worn by Debbie), and "Nobody knows I'm a lesbian" (worn by a woman)