The map Cindy reads in the car has the following text on the bottom: "Directions: If you had any brains you would take your ass home. But since you don't, head North 2 miles on Hades Divide. You will pass Elm St. on your left. Whatever you do, KEEP MOVING! 6 Miles to Kane Manor. If you reach Compton, lock your door, bend over, and kiss your ass goodbye!"
Marlon Brando was paid $1 million to play Father McFeely in the The Exorcist (1973) spoof at the beginning of the film. He took the money and accepted the role, but got pneumonia a few days before shooting his scenes. He dropped out of the project, but was still allowed to keep the money, and was replaced by James Woods.
According to Tori Spelling, her character, Alex Monday, was originally one of the leads. However, after refusing to do a scene where she had to be topless, Dimension Studios cut her out of more than half the movie. After that, her role was simply known as a "cameo", even though she was originally in 3/4 of the film.
The streets and names on the map that Cindy reads are all significant to horror films or horror lore. Hades Dr. is a reference to Hades, Greek God of the Underworld; Elm St. is an obvious reference to A Nightmare on Elm Street (1984); and Kane Manor is either a reference to Kane Hodder, who played Jason Voorhees in four Friday the 13th films or the character Kane, from Poltergeist II: The Other Side (1986) and Poltergeist III (1988).
Powerpuff Girls merchandise is shown twice in the film. The first appearance is on Alex's bag when she is introduced and walking with the other girls, and the second is a large plastic figure of Blossom on a shelf in Cindy's room near the end of the film.
The name of the house featured in the film, "Hell House" was intended of a spoof of "Hill House," which was featured in The Haunting (1999). The Wayans Brothers later admitted being totally unaware that the name "Hell House" was also used in a Richard Matheson novel and the film version of that novel, The Legend of Hell House (1973).
Composer George S. Clinton originally wrote a 70-minute, full orchestral score for the film but it was ultimately rejected in favor of the style of the temp score. Most of the temp score was compiled from recordings of Marco Beltrami's work, and he was asked to score the film. However, Beltrami did not have the time to do it, and thus hired 11 other people to write music.
Natasha Lyonne, who plays the possessed girl at the beginning, and James DeBello, who plays the guy with the "Fucked Me" tattoo, previously appeared with Shannon Elizabeth in American Pie. Elizabeth played Buffy in the first Scary Movie.
Drew Barrymore and Linda Blair are the only two actors to appear in films parodied by the first and second Scary Movies. They both made cameos in Scream (1996), which is parodied in the first one. Blair starred in The Exorcist and Barrymore starred in Charlie's Angels, which are both parodied in this one.