Lu tries to help injured single mom, Melissa Nauls, who's addicted to Crystal Meth keep custody of her three kids. But when Melissa dies after going back to a crystal meth lab Lu has to find a way to keep all three kids together as Christmas approaches. Meanwhile, Kayla is attracted to blind patient Will Manning which makes Peter very jealous.
Kayla loses a patient who was a bank robber, only for his unstable girlfriend Jamie to show up at the hospital with a bomb strapped to her body. Meanwhile, 35-week pregnant Sirena Adkins is brought in suffering from meningitis and her mom tells Lu to only save the daughter and not the baby.