Meryl and Milly are searching for the Legendary "Vash the Stampede". They are rumored that it is a man that is twelve feet tall and has a green mohawk. A while later they meet a man befitting the description, but this man has already captured a man that he is convinced is Vash.
Vash is looking for a renowned gunsmith named Frank Marlon. He finds him - but the legendary craftsman is a drunken mess! Making things worse, a group of bandits has learned that there's no sheriff in town!
Vash finds himself in the middle of a hostage crisis when outlaws take the mayor's daughter - and Meryl and Milly - captive. He quickly discovers that these bad guys might not actually be the bad guys!
Vash is completely smitten with Elizabeth, a stunning beauty who has arrived in town to repair the local plant. Hopefully Vash isn't too distracted by her charms - because the enemy is very close indeed.
A bus trip is interrupted to pick up a priest with a giant cross, Nicholas D. Wolfwood. Large robots attack the bus as it leaves. A small child is left behind and Vash and the newcomer get out to fight the robots and save him.
An elderly couple asks Millie and Meryl to help them protect a piece of valuable property from their rivals. With hired killers nearby, and Vash nowhere to be found, Meryl and Millie might be in over their heads.
The Roderick gang's battle with Legato is violently interrupted by the fierce Gung-Ho Guns. Just as Vash begins to investigate the incident, he meets Dominique the Cyclops, a lethal beauty with an amazing power.
Meryl and Millie are doing their best to get by as Vash recovers, but when the locals discover that the infamous gunslinger is nearby, they set out to make him pay for their recent pains - with his life.