"Rat Race" has an extremely similar plot to the film It's a Mad, Mad, Mad, Mad World (1963), in which a group of strangers are caught up in a mad dash to seek out and claim $350,000 in cash. That amount adjusted in inflation from 1963 to 2001 would come out approximately to $2,000,000 - the same amount of money Donald Sinclair offered to the 6 random gamblers. Whether or not this was intentionally written into the script as an homage to the 1963 film is unknown.
Vince Vieluf who portrays Blaine Cody, did not appear on any of the film's posters or promotional material, even though he is one of the main characters, due to an agent who tried to secure star-billing. Vieluf has since fired the agent.
DVD extras includes unplanned, unscripted, recorded phone calls to the main stars of the movie from Jerry Zucker and Andy Breckman, who were sitting in a sound studio working on an audio commentary for the movie. Jerry and Andy said it was simply something they came up with because they were trying to find things to include on the DVD.
Professor Ken Freedman, mentioned in the speech by the jet car driver before the women steal the car, is a reference to Ken Freedman, the station manager of WFMU where the writer and he do a weekly radio show, 7 Second Delay.
When Tracy drags her boyfriend out of the truck and drives off in it after making him crash, you can clearly see that there are two seat belts for the driver and front passenger. The truck is an extended cab Dodge Ram, which has the seat belt upper mounts on the pillars behind the doors. The front seat came from a quad cab Dodge Ram, which required the seat belts to be mounted completely within the seats due to the way the rear doors open.