Nick volunteers on his birthday to take a case involving a 16-year-old girl found dead in the parking lot of a seedy hotel, because he got to know the girl while investigating other cases at the hotel over the last year.
A young Hollywood actress is killed in what appears to be a simple drunk driving collision, but the team soon suspects that there is more to the case than meets the eye, and a shootout in the crime lab may confirm their suspicions.
CSI tackles a case involving a young man who was brutally raped and beaten, and a case involving the shooting death of an electronics store owner. But they soon discover that the two cases are directly related.
CSI tries to figure out who put a severed head in the ball return during a championship bowling match, while Dr. Langston reinvestigates the case of a wife accused of shooting her husband after the wife kills herself in her prison cell.
Henry's surprise birthday party turns into disaster when the guys discover a dead body in a shut-down, out-of-the-way barbecue joint. Back in the lab, Dr. Langston discovers that "Dr. Jeckyl" has struck again.