The parents of a missing girl are found murdered in a seedy motel room, and a registered sex offender now working as a church pastor is suspected. Meanwhile, Sara tackles a case involving a dead homeless man.
The hanging death of a possible hermaphroditic male is connected to a tainted water supply, while the day crew investigates 40-year-old skeletal remains found at the site of a recently-imploded casino.
CSI investigates the death of a toddler who was left in a cardboard box in a parking lot. A registered sex offender who is wrongly accused threatens Catherine after the real cause of death is identified.
A temperamental sitcom actress is found dead in her Las Vegas hotel room, and there are plenty of suspects. Soon afterward, her photo double is also killed, this time in Hollywood in the dead actress' car.