A young Hollywood actress is killed in what appears to be a simple drunk driving collision, but the team soon suspects that there is more to the case than meets the eye, and a shootout in the crime lab may confirm their suspicions.
CSI tackles a case involving a young man who was brutally raped and beaten, and a case involving the shooting death of an electronics store owner. But they soon discover that the two cases are directly related.
CSI tries to figure out who put a severed head in the ball return during a championship bowling match, while Dr. Langston reinvestigates the case of a wife accused of shooting her husband after the wife kills herself in her prison cell.
Henry's surprise birthday party turns into disaster when the guys discover a dead body in a shut-down, out-of-the-way barbecue joint. Back in the lab, Dr. Langston discovers that "Dr. Jeckyl" has struck again.
After finding a new dead body, Langston and Brass uncover a connection to an unlicensed doctor who may be "Dr. Jekyll." Meanwhile, Willows discovers that two women found dead in a hotel were con women who preyed on an unsuspecting actuary.
Hodges and Wendy pose as CSIs to impress a group of "Crime Cadets" and get some help in solving a crime, and Hodges becomes jealous when Henry asks Wendy out. Meanwhile, Nick and Greg solve a bacteria outbreak at the police station.
A comic who was one-half of a legendary Vegas duo from the 1970s is found dead on the eve of their reunion show, while the body of a fugitive who bombed an abortion clinic is dumped in Las Vegas with over 100 bullet holes in him.
The crime lab reluctantly brings in imprisoned serial killer Nate Haskell after he claims to know the identity of "Dr. Jeckyll." Meanwhile, clues revealing his next and perhaps final victim are mailed to Dr. Langston.