Enterprise agrees to escort Tellarite delegates to peace talks with Andorians. En route they rescue several Andorians who abandoned the ship Kumarr, who insist it was Tellarites who attacked them. When Enterprise is soon attacked by the same ship which now appears to be a Andorian ship, Archer must prove to the warring races that a third party must be setting them up to fail at their attempt at peace.
While Enterprise is at Earth, Phlox is abducted by the Klingons and forced to research a cure for a virus destined to wipe out the race. Reed is tapped by a secret agency and ordered to betray Archer. Trip transfers to the Columbia.