When Mr. Potter (played by Jeffrey Jones) calls the operator and asks for the number for Dr. Dolittle, he says "Not Stuart Little, Dolittle." Ironically, Jeffrey Jones played Uncle Crenshaw in Stuart Little a couple years earlier.
In An episode of Friends (1994) Joey rents a movie called dr. Do me a little, which is supposed to be a pun to this movies title, Lisa kudrow who played Phoebie in Friends was the voice of one of the animals in Dr Dolittle 2
Steve Zahn is the voice of Archie the Bear. He has previously costarred with Eddie Murphy in "Daddy Day Care." Later he would appear on "Friends" to play the gay ice dancer ex-husband of Phoebe (played by Lisa Kudrow). Lisa Kudrow plays the voice of Archie the Bear's love interest Ava the Bear.
The two young bears at the end of the movie are Little Bart and Honey Bear, also owned by famed grizzly trainer Doug Seus, and the subject of two Animal Planet specials. The two bears, who were cubs at the time, were on the set at the time of filming and the director decided to add the final scene after seeing them.