Though the film takes place at schools in Ithaca, Boston, and Austin, almost all of the college scenes were filmed at Georgia Tech, Emory University, and the University of Georgia, all near Atlanta.
The motel clerk reads an issue of Celebrity Skin magazine with Drew Barrymore on the cover. At the time, Drew Barrymore was engaged to actor Tom Green, who plays Barry Manilow in this movie.
Each College in the movie, other than the University of Tennessee, is altered from names of real colleges. For example, University of Ithaca does not exist but is supposed to spoof Ithaca College and Cornell, neither does University of Austin which is a spoof of University of Texas, or University of Boston which could spoof Boston College, or Boston University
Although there is no actual Ithaca University, the writers (Todd Phillips and 'Armstrong, Scot') both are alumni of Ithaca College in Ithaca, NY, and the movie is partly based on their time there.
Originally, Moby's version of the James Bond theme was playing in the background when E.L. drove the car over the bridge. However, Director Todd Phillips later switched it to a 'generic' song, because the budget didn't allow him to use the Moby song.
When E.L. asks for "help" from the nurse working at the sperm bank she says, "The best results seem to be obtained through fantasization accompanied by masturbation followed by ejaculation." This line was taken from a similar scene in The Right Stuff, where Gordon Cooper asks for help from Nurse Murch.