Brandy Ledford originally auditioned for the part of Andromeda, which went to Lexa Doig. When Lexa was unavailable due to her pregnancy during the fifth season, they created Doyle to do much of Rommie's work.
The basic premise of Andromeda - man from an earlier era piecing civilization back together - was the subject of three earlier Roddenberry pilots: "Genesis II" starring Alex Cord, and "Planet Earth" and "Strange New World" starring John Saxon.
Many Nietzscheans share their first names with historical or mythological figures. Tyr is the Norse God of Warfare. Tyr Anasazi's parents are Victoria (after the British Queen) and Barbarossa (after the German emperor of the Holy Roman Empire, Frederic Barbarossa). Charlemagne Bolivar, leader of the Sabra-Jaguar Pride, takes his names from the French Emperor Charlemagne and Simón Bolívar, the South American freedom fighter.
The quotation which opens the 100th episode of the show ("Pride Before the Fall") includes an oblique reference to two of the show's production companies, Tribune Entertainment and Fireworks. The same episode closes with a blooper reel under the credits.
Ryan, Doyle, Rommie, Trance Gemini and Ione are Avatars. An avatar is a manifestation of a deity or released soul in bodily form on earth and an icon or figure representing a particular person in a computer game. The series premiered 9 years before the James Cameron film Avatar (2009).
Dylan Hunt shares his name with Dylan Hunt, a character from Gene Roddenberry's TV movie Genesis II (1973), like Dylan Hunt in this series, the Dylan Hunt of that TV movie also goes into suspended animation and is revived centuries later.
When Andromeda goes into warp speed, it's called "Slipstream". Slipstream is when airstream is pushed back by a revolving aircraft propeller. There was a science fiction film starring Mark "Luke Skywalker" Hamill called Slipstream (1989).
One of the main characters in the series is called Trance Gemini. A trance is a half-conscious state characterized by an absence of response to external stimuli, typically as induced by hypnosis or entered by a medium. Gemini is the third sign of the zodiac, which the sun enters about 21 May.