According to the DVD commentary, the car chase scene was originally meant to be a spoof of Ronin (1998). When the filmmakers go to the location, they saw how quickly the lights changed, realized it would be a funnier joke, and rewrote the scene (the lights really do change from green to red as fast as they are shown in the movie).
The scenes at the "Surf and Turf" restaurant were filmed at a Port Washington, NY restaurant called "Louie's". The car racing scenes between Ben Stiller and Robert De Niro were also filmed in downtown Port Washington. Also, the scene where Stiller and De Niro go shopping is in Port Washington at Salem Drugs.