12 genetically enhanced childern escape from a military base that created them. 10 years later, after The Pulse, a magnetic bomb that destroyed every computer in USA, has struck, Max Guevara, one of the 12 escapees, is a bike messenger in (what's left of) Seattle and with cyberjournalist, Logan Cale, she tries to rid the world of crime and corruption, avoid her creators and uncover her past.
In a post apocalyptic world genetically enhanced female (transgenic) Max Gueverra tries to stay ahead of the law while looking for links to her past. Max does a job for Logan (the last good man on Earth; and cyber journalist Eyes Only) while trying to keep a handle on her revved up hormones, thanks to Manticore. Logan manages to turn up some information on a friend from Max's past.
Max needs her pills to keep her seizures at bay but her friends believe that she's an addict. Max is feeling the serious side effects from the alterations to her biochemistry. After her friends flush her pills she tries to steal some from the local hospital but get's caught and lands up in jail.
Alina Herrero contacts Eyes Only and asks him to help her find out the truth about her father's disappearance years ago. Max breaks in to the police department to steal information about her father, who also happens to be Logan's mentor. At the same time, Sketchy loses the mob's money and has to return the full amount in 36 hours. Max uses her super skills to win the money through poker.
Max hires a private detective to help her track down a fellow X-5 called Zack. She is about to receive vital information when the detective is found dead. Back at Logan's place, his ex-wife Valerie shows up unexpectedly with an obvious hidden agenda. Max decides to find out the truth about her.
Max and Donald Lydecker are taken hostages at a convention. Logan decides to trade himself as a hostage for all the women. Max decides to stay and ends up helping Logan when the terrorists push him off the roof of the building. She also does the unexpected when she saves Lydecker from being shot in the head.
Brin contacts Zack before she is captured. Max and Zach has no choice but to force Lydecker to tell her whereabouts. They teamed up and follow Brin to a military facility where Brin is to be sold to the highest bidder. Once there, Lydecker double crosses the two X-5s and decides to be in on the sale. Max and Zack manage to escape from captivity with Brin who is suffering from a condition that speeds up aging. She has no choice but to receive help from Lydecker. Max and Zack accept Brin's decision and leave her to be picked up by the man who made them.
Now that Lydecker has seen her face, Max is on a Wanted poster all over town for a murder she didn't commit. The temptation of the big reward leads even her own boss, Normal, to give her up to the police. Zack and Logan help her escape to Logan's cabin located outside of Seattle. However, when Max learns that Logan's condition has worsened and that he's undergoing a very dangerous surgery, she risks her life to come to the hospital. Logan has lost a lot of blood and the blood bank runs out of AB negative blood. Max gives Logan a transfusion as she is a universal donor...