Flashbacks in interview style recall a telling incident in the lives of Rick, Karen, Sam Blue's estranged wife Jeannine, and Sam himself, who rues another dalliance. Also, when Sam and Judy's relationship becomes the talk of the whole family, Sam finally realizes he wants Judy to be more than just a friend. Meanwhil,e Karen's loneliness and discomfort is compounded when Jessie cancels plans with her mother to stay at Lily's house.
A tragic accident shakes Karen from her deep depression and sets her up for the toughest battle of her life. This makes Eli and Jessie learn the hard way that their parents are more fragile than they'd thought.
Jessie's anxiety and guilt about her mother's slow recovery causes tension with every member of the family, especially Lily. Meanwhile, Eli is in denial about the seriousness of his mother's condition.
Grace decides to join the Gay-Straight Alliance to be closer to Mr. Dimitri. Lily wonders about her daughter's sexual orientation while Jessie does not know how to face the fact that her friend Katie used to have a girlfriend.
Sam places his dream of committing to Judy and having a family squarely on the shoulders of his eleven-year-old son. Meanwhile, Jake finally realises his feelings for Tiffany and his new baby daughter.
Rick and Lily face more life-altering decisions when he is offered a major architectural position in Australia and she is offered a chance to take her Chicago-based radio show into national syndication.