Along with the remake, this is the only "Biohazard"/"Resident Evil" to feature a "best-case-scenario" ending which does not elude to a possible sequel or spin-off and suggests that "everything is finally over". The reason for this is possibly because the company was uncertain how well the game would be received, so this game could stand on its own story-wise if it failed economically.
The game was renamed from it's original Japanese title "Biohazard" because it would be almost impossible to register the name in America. Capcom's Chris Kramer points out that both a "Crappy DOS-based game" and a New York-based Punk band were both named "Biohazard" in the US. This caused the team to have a company-wide contest to rename the game. The winner was, of course, "Resident Evil".
Completely redone for the Nintendo GameCube. Including better graphics, CG FMVs (rather than live-action), item placement different and other goodies. Part of Resident Evil/Biohazard exclusive GameCube deal which includes ports of Biohazard 2,3 and Code:Veronica as well as Biohazard 0.
There was an unreleased colorized introduction that showed a graphical death scene where Joseph Frost gets mauled by a Cerberus. This was supposed to be released in this director's cut, but because of a technical error, they put the same original black and white introduction.
The Japanese version used the English dub even though Capcom recorded a Japanese version. This was, ironically, because Capcom thought the Japanese dub was too horrible. Funny enough the English dub is considered some of the worst in video game history.
Bravo Team's pilot, Dewey, was originally conceived as a thin African-American member of STARS who would've also served as the game's comic relief. He and another character named Gelzer (a giant man with cybernetic implants) were planned to appear in the game, but were discarded from the final version. The Edward Dewey in Biohazard 0 is a tall Caucasian and is a departure from the character's initial concept.
Chris Redfield's story continues in Resident Evil 2 (via a message telling his sister about his whereabouts), Resident Evil Code Veronica, Resident Evil 5, & Resident Evil 6. Jill's story continues in Resident Evil 3, Resident Evil Revelations, & Resident Evil 5.
Albert Wesker is the only Resident Evil character that appears or is mentioned in every Resident Evil games except for the spinoffs. He is pretty much the catalyst for the whole series. In Resident Evil 0 he appears in certain cutscenes. In Resident Evil 2 & 3 the player can find his desk in the S.T.A.R.S' office. If examined the player will say that it belongs to Wesker, leader of the S.T.A.R.S unit. In Resident Evil 4 he is mentioned by Ada Wong and seen on a small monitor. In Code Veronica he plays a vital role in the storyline, appearing in certain key moments. In Resident Evil 5 he is the main antagonist. In Resident Evil 6 he is mentioned by Chris Redfield when Chris is talking to Jake, Wesker's son.
This game has seen the most releases out of all the Resident Evil games. These include the Playstation 1 version, the Sega Saturn version, the PC version, the Nintendo DS version, and the unreleased Gameboy Color Version.
It is impossible to have all four characters live in the end (Chris,Jill,Rebecca, & Barry). The two best possible endings have Chris, Jill, & Barry surviving or Chris, Jill, & Rebecca surviving. Either way Barry appears later in the series, but Rebecca is never mentioned again besides finding her desk in the S.T.A.R.S' office in RE2 &RE3. It would appear as though Rebecca did survive the events of RE0 & RE1.