Along with the remake, this is the only "Biohazard"/"Resident Evil" to feature a "best-case-scenario" ending which does not elude to a possible sequel or spin-off and suggests that "everything is finally over". The reason for this is possibly because the company was uncertain how well the game would be received, so this game could stand on its own story-wise if it failed economically.
Completely redone for the Nintendo GameCube. Including better graphics, CG FMVs (rather than live-action), item placement different and other goodies. Part of Resident Evil/Biohazard exclusive GameCube deal which includes ports of Biohazard 2,3 and Code:Veronica as well as Biohazard 0.
Bravo Team's pilot, Dewey, was originally conceived as a thin African-American member of STARS who would've also served as the game's comic relief. He and another character named Gelzer (a giant man with cybernetic implants) were planned to appear in the game, but were discarded from the final version. The Edward Dewey in Biohazard 0 is a tall Caucasian and is a departure from the character's initial concept.
The game was renamed from it's original Japanese title "Biohazard" because it would be almost impossible to register the name in America. Capcom's Chris Kramer points out that both a "Crappy DOS-based game" and a New York-based Punk band were both named "Biohazard" in the US. This caused the team to have a company-wide contest to rename the game. The winner was, of course, "Resident Evil".