| Rosanna Arquette | ... | Kara Dimley (1 episode, 1987) |
| Candice Bergen | ... | Barbara (1 episode, 1987) |
| Teri Garr | ... | Robin Stone (1 episode, 1987) |
| Spalding Gray | ... | Gary (1 episode, 1987) |
 | Steven Wright | ... | Dwight Harper (1 episode, 1987) |
| Stockard Channing | ... | Hilda Bundt (1 episode, 1989) |
| Carrie Fisher | ... | Enid (1 episode, 1989) |
| Sally Kirkland | ... | Agripina Gravanescu-Smith (1 episode, 1989) |
| Robert Klein | ... | Buddy Amber (1 episode, 1989) |
| Jean Stapleton | ... | Edna (1 episode, 1989) |
| Jessica Harper | ... | Sydney (1 episode, 1987) |
| Tim Matheson | ... | Mitch (1 episode, 1987) |
| Ted Stidder | ... | Fred (1 episode, 1987) |
| John Stockwell | ... | Maxwell Fletcher (1 episode, 1987) |
| Lyman Ward | ... | George Stone (1 episode, 1987) |
| Griffin Dunne | ... | David (1 episode, 1989) |
| Corey Feldman | ... | Bill (1 episode, 1989) |
| Sheila McCarthy | ... | Jenny Amber (1 episode, 1989) |
| Judge Reinhold | ... | Jed (1 episode, 1989) |
| Peter Scolari | ... | Howard LaMotta (1 episode, 1989) |
| Louie Anderson | ... | Stu (1 episode, 1987) |
| Catherine Bach | ... | Actress (1 episode, 1987) |
| Hagan Beggs | ... | Dad (1 episode, 1987) |
| Hope Lange | ... | Frances Fletcher (1 episode, 1987) |
| Ketty Lester | ... | Mildred (1 episode, 1987) |
| Gail Boggs | ... | Luanda (1 episode, 1989) |
| Anne De Salvo | ... | Nancy (1 episode, 1989) |
| Katherine McGrath | ... | Mother St Helen (1 episode, 1989) |
| Linda Purl | ... | Laura (1 episode, 1989) |
| Danitra Vance | ... | Emma St. John (1 episode, 1989) |
| Dustin Berkovitz | ... | Young Gary (1 episode, 1987) |
| David Byrne | ... | Byron (1 episode, 1987) |
| Bruno Gerussi | ... | Harry (1 episode, 1987) |
| Betty Phillips | ... | Mom (1 episode, 1987) |
| Ruth Springford | ... | Dr. Iris Goldberg (1 episode, 1987) |
| Richard Dimitri | ... | Dean (1 episode, 1989) |
| Alejandra Gollas | ... | Jennifer (1 episode, 1989) |
| Jerry Houser | ... | Gene (1 episode, 1989) |
| Marcell Rosenblatt | ... | Tracy (1 episode, 1989) |
| Al Ruscio | ... | Father (1 episode, 1989) |
| Melanie Jones | ... | Gary's Mom (1 episode, 1987) |
| Catherine O'Hara | ... | Rebecca (1 episode, 1987) |
| Keanu Reeves | ... | Joey (1 episode, 1987) |
| Robert Ridgely | ... | Marlin Fletcher (1 episode, 1987) |
| Ron Silver | ... | Driving Instructor (1 episode, 1987) |
| Eric Ayala | ... | Young Benjie (1 episode, 1989) |
| Buck Henry | ... | The Man on TV (1 episode, 1989) |
| Kurt Knudson | ... | Jack (1 episode, 1989) |
| Jon Polito | ... | Agent Caponello (1 episode, 1989) |
| Tracy Brooks Swope | ... | Allison (1 episode, 1987) |
| Anne Ramsey | ... | Gypsy (1 episode, 1987) |
| Jeff Schultz | ... | Frank (1 episode, 1987) |
| Doug Tuck | | (1 episode, 1987) |
| Laura White | ... | Jennifer (1 episode, 1987) |
| George Belanger | | (1 episode, 1989) |
| Kalimba | ... | Abdul (1 episode, 1989) |
| Max Perlich | ... | Older Benjie (1 episode, 1989) |
| Ken Smith | | (1 episode, 1989) |
| Jay Brazeau | ... | 2nd Driving Instructor (1 episode, 1987) |
| Norman Browning | | (1 episode, 1987) |
| Jackson Davies | ... | Charlie (1 episode, 1987) |
| John Steadman | ... | Grandpa Buckshot (1 episode, 1987) |
| Álvaro Carcaño | | (1 episode, 1989) |
| Ellen Gollas | | (1 episode, 1989) |
| Dondee Spencer | ... | Clarissa (1 episode, 1989) |
| Alex Bruhanski | ... | Bruno (1 episode, 1987) |
| Brandon Call | ... | Reggie (1 episode, 1987) |
| David Alden | | (1 episode, 1989) |
| Gabriela Goldsmith | | (1 episode, 1989) |
| Ron Wertheim | | (1 episode, 1989) |
| Janne Mortil | | (1 episode, 1987) |
| Jaqueline Fernandez | | (1 episode, 1989) |
| John Sabol | | (1 episode, 1989) |
| Irina Areu | | (1 episode, 1989) |
| Jeff Daniels | ... | Jim (1 episode, 1987) |
| Christopher Durang | ... | The Waiter (1 episode, 1987) |
| Julie Hagerty | ... | Marsha (1 episode, 1987) |
| Swoosie Kurtz | ... | Wanda (1 episode, 1987) |
| Roger Cudney | ... | Persival (1 episode, 1989) |
| Geena Davis | ... | Daphne (1 episode, 1989) |
| Nancy Lenehan | ... | The Neighbor (1 episode, 1989) |
| Peter Riegert | ... | Bill (1 episode, 1989) |
