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The following FAQ entries may contain spoilers. Only the biggest ones (if any) will be covered with spoiler tags. Spoiler tags are used sparingly in order to make the page more readable.
For detailed information about the amounts and types of (a) sex and nudity, (b) violence and gore, (c) profanity, (d) alcohol, drugs, and smoking, and (e) frightening and intense scenes in this movie, consult the IMDb Parents Guide for this movie. The Parents Guide for Blade II can be found here.
Blade II is based on a vampire hunter featured in Marvel Comics. He was created by Marv Wolfman and Gene Colan. Blade's first appearance was in The Tomb of Dracula #10 (July 1973) as a supporting character. The comic book Blade was adapted for the movie by American screenwriter David Goyer. The first Blade movie, Blade, was released in 1998, followed by Blade II. A third sequel, Blade: Trinity followed in 2004.
While it's never explicitly stated, Blade is seen with a large supply of Serum, in much smaller bottles from the first film. The amount of these he has suggests he does not need to increase his dose - Chances are, once she developed this, Karen left - either to return to a normal life or to join another group.
There are a number of theories: (1) A line of dialogue from the film explains "He shot himself and then he turned." says Rush, the vampire Blade allows to leave as a "loose end" for showing him Whistler; (2) Director Guillermo Del Toro argued that no one saw Whistler shoot himself (in the DVD commentary), so he really didn't die in Del Toro's eyes; and (3) A deleted scene from "Blade." When Blade and Karen were climbing out into the daylight after Blade had just blown up Deacon Frost, there was a figure in the background that appeared to be Whistler. It was hinting at him returning in a sequel, but they decided to leave it out of the film. (Probably because they didn't know if a sequel was to happen yet.)
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