The Fantastic Four journey to Attilan and assist the Royal Family in restoring Black Bolt to the throne, but must contend with Black Bolt's treacherous brother Maximus and the swarms of Inhumans loyal to him.
Earth's environment runs haywire as Ego, the Living Planet, a unique monstrous planetoid creature that devours planets just like Galactus, enters the solar system. To repel it, the Fantastic Four join forces with the mighty Thor.
Black Panther, the king of a secretive high-tech African tribe, challenges the Fantastic Four. Once defeated, he asks for their help to stop Ulysses Klaw, a mad scientist who killed his father and wants the tribe's powerful alien ore.
Galactus' new slave and herald, double-crossing Terrax, asks Fantastic Four for help. However, Johnny's Inhuman girlfriend Frankie supports Galactus. Thor arrives to help the Fantastic Four and even mythical Ghost Rider intervenes.
The Fantastic Four stops the Skrulls once again, but Sue ends up in a coma and her dad is framed. The Skurlls also send Super-Skrull again, this time masked as Sue. Meanwhile, Skrull warlord Morrat tries to take over the Skrull empire.
The Fantastic Four help Black Bolt save his people - the Inhumans - who live imprisoned under an unbreakable dome guarded by a simple, but relentless robotic sentry, who misunderstood his orders to protect the Inhumans forever.
Wishing to take over the world, Dr. Doom steals Silver Surfer's power cosmic again and becomes literally unbeatable. The Fantastic Four's figure that the only thing stopping him now is Galactus' power.