Brian helps Stewie meet Miley Cyrus before her concert in Quahog, and they discover a secret about her identity. Meanwhile, the family discovers that the evil monkey in Chris's closet isn't actually evil.
When Brian accidentally kills another dog he is surprised to see that no one cares so he tries to convince everyone that the life of a dog should have the same value as a human one. Meanwhile, Lois hires a maid who doesn't listen to Peter.
The Griffins are invited to be contestants on the game show "Family Feud." After winning the game and advancing to the show's bonus round (called Fast Money), Lois puts the Griffins in prime position to win the game, but Peter bungles the opportunity when he stubbornly refuses to change his answer to the first question. Host Richard Dawson tries to remind Peter of the rules, but when Peter continues to argue and grabs Dawson, he gets pushed through a podium on the set and is knocked unconscious. At the hospital, Dr. Hartman tells Lois that Peter has amnesia. At home, ...
Brian sells his pilot for a heartwarming family drama to CBS, who then turns it into a lame, formulaic sitcom starring James Woods. Meanwhile, Meg and Chris try to hide Stewie's accidental injury they caused from their parents.
In the special one-hour 150th episode event set in real time, Brian and Stewie (voices of Seth MacFarlane) get locked in a bank vault where they are forced to deal with each other on a whole new level. The episode also includes never-before-seen musical footage on the very special 150th episode of Family Guy!
Lois agrees to become a surrogate mother for a friend who is unable to conceive a child of her own. But when the friend and her husband are killed in a car accident, Lois and Peter consider whether to terminate the pregnancy.