Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <email@example.com>
Early in the movie, Thrax is called "La Muerte Roja" (The Red Death), name of the killer plague in Edgar Allan Poe's short story "The Masque of the Red Death". See more »
Chill was sent into Frank as a flu vaccine. While he could have been a live, weakened virus had he been administered via LAIV (FluMist), this variety of the vaccine was not introduced until 2 years after the film was released. So Chill would have had to come from an injection, meaning he would be a dead virus. See more »
La Muerte, man! Esta aqui! He's gonna kill us dead, hombre!
No, no. Talk English, man. We ain't on Telemundo here.
La Muerte Roja! He's coming, man! I saw him!
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The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »
A Great Class of Hygienic and Human Body Functions
Frank (Bill Murray) is a widow without hygienic and bad alimentary habits. He eats food that felt on the floor without cleaning, he does not wash his hands before eating and he eats only junk food. His daughter keeps unsuccessfully trying to correct his behavior. One day, Frank eats a dirty egg and gets a disease. From this moment on, the human body functions are showed through very funny and educational cartoons. The hero, Osmosis Jones, is a white globule, with Chris Rock's voice. The great Farrely brothers again surprise me. This funny (and sometimes scatological movie) is a great class of hygienic and human body functions. Chris Rock and Laurence Fishburne give a great performance with their voices. Bill Murry has the role of a disgusting character. An excellent and very educational movie, indicated also (or specially) for children. My vote is nine.
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