Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <firstname.lastname@example.org>
Warner Bros. animation was in serious financial trouble during the film's production, and in 2000 it came down to two options, green-light another film by Director Brad Bird who made the critically acclaimed film The Iron Giant (1999), or this film, Warner Execs choose this film over Bird's and upon learning this Bird got so mad at Warner Bros. that he took his film with him to Disney and Pixar animation to be made, that film would be the highly successful The Incredibles (2004), whereas this film bombed at the box office, was critically panned, and ultimately killed Warner Bros. Feature Animation. See more »
Chill was sent into Frank as a flu vaccine. While he could have been a live, weakened virus had he been administered via LAIV (FluMist), this variety of the vaccine was not introduced until 2 years after the film was released. So Chill would have had to come from an injection, meaning he would be a dead virus. See more »
Hey, I was injected into this body to rat on influenza only, and this don't sound like influenza to me. Now beat it.
I'm sure Johnny Streptacoccus and the Melanoma Brothers would be very interested to know about your flu shot work.
You can't jack me on that, brother. I'm on the Virus Protection Program.
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The opening credits are shown on strands on amoeba. See more »
I can't believe this movie made such little money it's sad cause it's a very cute and original idea. It's fun to watch how the pill and blood cell travel to different parts of the body. And Bill Murray is good as usual, and Chris Rock's voice fits in with the main character rather well too. I wish the real story could have been put in a little more and the daughter character a little less, plus Chris Elliott is a terrible actor. But overall the movie isn't bad and it's fun and cute, 7/10
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