Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <email@example.com>
The raindrops outside the news stand look like sperm cells. See more »
In the scene where Frank converses with the oyster boy, the latter says something about 'the oysters should be edible...if my hypothenuse is correct'. The correct line is 'if my HYPOTHESIS is correct.' See more »
Excuse me sir, would you like to see a free screening? We've got a live theater broadcasting dreams all the way from the subconscious in the brain.
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The opening credits are shown on strands on amoeba. See more »
The stand-out comedy of 2001- someone has a big imagination
Whoever made this has a big imagination about what goes on inside the human body. It's very witty and smart. The whole rookie cop cliche who messes up and is THIS close to being pulled off the force and has a hunch a teams up with an unlikely buddy and ends up being right (for example, Rush Hour) is being given a whole new twist. The Farrley Brothers have done it again- and made a solid B+ stand out comedy. B+, 8/10
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