Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <firstname.lastname@example.org>
When Frank's daughter decides not to go to Buffalo with him, we see the ticker above his door showing the scores of various sports games. The item "Seattle: 5 Oakland: 4" scrolls onto the screen in two consecutive shots. See more »
[Osmosis is at the theater watching one of Frank's dreams when the screen appears to burn up]
Thrax is alive! Thrax is alive and he's in the brain!
Oh, sure, pal! Spoil the ending.
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The opening credits are shown on strands on amoeba. See more »
I can't believe this movie made such little money it's sad cause it's a very cute and original idea. It's fun to watch how the pill and blood cell travel to different parts of the body. And Bill Murray is good as usual, and Chris Rock's voice fits in with the main character rather well too. I wish the real story could have been put in a little more and the daughter character a little less, plus Chris Elliott is a terrible actor. But overall the movie isn't bad and it's fun and cute, 7/10
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