Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <email@example.com>
The population of the City of Frank is 78,899,293,934,872,302,829,287,438. See more »
During the beginning when Ozzy is patrolling the mouth in a helicopter, there is a shot where some of the bubbles of egg and saliva very quickly shift position. This is likely an animation error. See more »
[after almost dying, but returning to life; to Shane]
Your momma says "hi".
See more »
The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »
Don't Be Mad
Written and Produced by Mike City
Performed by Sunshine Anderson featuring Rayshawn Sherrer
Sunshine Anderson appears courtesy of Soulife Entertainment Holdings, Inc./
Atlantic Recording Corp.
Rayshawn Sherrer appears courtesy of Soulife Entertainment Holdings, Inc. See more »
Okay, I think I've found the Sadly Underrated Movie of the Year.
I think that, between this and "the Iron Giant", Warner Brothers Animation has GOT to spring for a better promotion department. Really, all they'd have to say is something like: "We just let the creators of 'Something About Mary' and 'Dumb and Dumber' make their own cartoon. Brace yourselves."
All complaints aside, and none of them are really the movie's fault, this is one of the most inventive animated films I've seen in a very long time. The characters and backgrounds are allowed to look and move in ways that are downright refreshingly bizarre. The visuals are very imaginative. The humor, while funny, is still very much what you'd expect from a Farelly Brothers movie that takes place inside a very sick man, so I wouldn't recommend it to little kids or the weak of stomach. If you have a little future A+P major, however, this is going to blow their mind. Give it a look!
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