Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <email@example.com>
The raindrops outside the news stand look like sperm cells. See more »
Chill was sent into Frank as a flu vaccine. While he could have been a live, weakened virus had he been administered via LAIV (FluMist), this variety of the vaccine was not introduced until 2 years after the film was released. So Chill would have had to come from an injection, meaning he would be a dead virus. See more »
Yo, where do you think you're going?
To get our cootie.
Looking like that? They'll tear you apart. You gotta get spiffy.
[Osmosis rearranges himself to look like a germ]
Check it out!
Hmm. Flexible cellular dynamics. What an ingenious defense mechanism. Ooh, let me try!
[Drix tries, only succedes in mangling his face]
What do you think?
I think you should guard the car.
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The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »
I wouldn't say this is one of the funniest movies I've ever seen, but there is definitely some original comedy here. I thought it was a very inventive story, and quite interesting. What shocked me more than anything about this film is the fact that it was directed by the Farrelly brothers, who also directed "Kingpin", "Dumb and Dumber", "There's Something About Mary", "Me, Myself and Irene", and "Shallow Hal". So this doesn't really fit their profile, but I'm glad to see that they are trying something new.
Like I said, not the funniest movie in the world, but it's good some good stuff in it. If you're a fan of the Farrelly brothers, then you'll probably want to see this film. If you aren't a fan of the Farrelly brothers, then you still may want to see this film, cause it's a little different than their other films. I hope you enjoy the film. Thanks for reading.
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