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Osmosis Jones (2001)

PG  |   |  Animation, Action, Adventure  |  10 August 2001 (USA)
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Ratings: 6.2/10 from 23,922 users   Metascore: 57/100
Reviews: 123 user | 81 critic | 28 from

A policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.


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Cast overview, first billed only:
Osmosis Jones (voice)
Thrax (voice)
Drix (voice)
Leah (voice)
Tom Colonic (voice)
Kidney Rock (voice)
Kenny Olson ...
Kidney Rock (voice)
Jason Krause ...
Kidney Rock (voice)
Kidney Rock (voice)
Stefanie Eulinberg ...
Kidney Rock (voice)
Jimmie Bones ...
Kidney Rock (voice)
Uncle Kracker ...
Kidney Rock (voice)
Additional Character Voice (voice)
Additional Character Voice (voice)


Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by Anthony Pereyra <>

Plot Summary | Plot Synopsis


She's got a jones for Osmosis. Leah. One hot hormone. See more »

Motion Picture Rating (MPAA)

Rated PG for bodily humor | See all certifications »

Parents Guide:





Release Date:

10 August 2001 (USA)  »

Also Known As:

Agent Bílá krvinka  »

Filming Locations:

Box Office


$75,000,000 (estimated)

Opening Weekend:

$5,271,248 (USA) (10 August 2001)


$13,596,911 (USA) (5 October 2001)

Company Credits

Show detailed on  »

Technical Specs


Sound Mix:

| |



Aspect Ratio:

2.35 : 1
See  »

Did You Know?


WILHELM SCREAM: Heard when Thrax (after kidnapping Leah) hijacks a vehicle and throws out the driver. See more »


When Osmosis comes back from "The Zit" he greets Leah by saying "Brandy- oh I mean Leah". Brandy Norwood was the voice of Leah. The error was left in because it was acted so well and was funny. See more »


Frank: Hey, partner, what you got there?
Oyster Boy: Oh, these? These are polluted oysters. Well, they WERE polluted. I replanted them in six weeks ago. That's how long the state says you gotta do it for. And every time the tide came in, it flushed all the bad stuff out.
Frank: Can you eat 'em?
Oyster Boy: Well, if my hypotenuse is correct...
Oyster Boy: sure. Y-y-yeah, definitely.
See more »

Crazy Credits

The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »


References Lethal Weapon 4 (1998) See more »


Cool, Daddy Cool
Written by Kid Rock (as Robert J. Ritchie), Bob Crewe and Frank Slay, Jr.
Produced by Kid Rock
Performed by Kid Rock featuring Joe C. (as Joe C)
Courtesy of Lava/Atlantic Records
See more »

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User Reviews

God help me, I really liked this film.
10 March 2004 | by (Edinburgh, Scotland) – See all my reviews

As an aesthete, this movie goes against everything I stand for, but I found it nonetheless very entertaining. It was like a peculiar yet satisfying mix between the Incredible Journey, Toy Story, and Lethal Weapon or Rush Hour (the whole loose-cannon, loner cop with a new partner bit).

I found the idea rather original: the human body is like a body of government, the cop is a white blood cell, the "president" was the cell whose will was that of the man (Bill Murray), the villain is a virus who hangs out in seedy areas of the body with shady characters, the bladder is a sort of train station/airport... clever stuff.

I did have issues with the "What a zit- I mean, what is it?" part, though: it landed on her lip! Wrong! I could have gone the rest of my life without seeing that. Molly Shannon is quite a sport. 7/10

14 of 21 people found this review helpful.  Was this review helpful to you?

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What disease is Thrax? jessie-mc
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It's 1am and it's on ITV why so late? vixsmith1982
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