Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <email@example.com>
Bill Murray's character mentions a "National Chicken Wing Festival" in Buffalo, New York. While the festival did not exist during the filming of the movie, this mention caused organizers to create an annual festival in Buffalo. See more »
The length of Frank's beard changes from scene to scene. See more »
Too bad you won't be here to see me break my record when I take down Frank's pretty little girl.
She ain't goin' down. You are!
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The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »
I thought this movie was very good. The people leaving bad reviews are being too critical. This movie was meant to be fun. The way the inside of the body is a city, the white blood cells are the police, fireman, etc., the lymph nodes were the police stations, veins were highways, the stomach was a bus station/airport type place, and the germs and bacteria were, of course, the criminals, and so on. This movie gives a very imaginative way the body works to fight infection, as if the body was a city of people just like in the real world. You may need to have some sort of knowledge about the body to get some of the puns and jokes, maybe not very young kids will get it, but they will like the animation...this movie is even good for adults. I give the movie 8/10...I thought it was a very entertaining movie!!!!!
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