Two dim-witted teenage boys, are forced to save the fast-food restaurant they work at from going out of business, despite a new-and-improved burger joint opening across the street that want to be the "Top Dog" in the fast food industry.
Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took, Drix arrives in the body and covers Frank's throat with ice to cover the irritation. Osmosis Jones becomes his newest partner. Now it's all up to only ... Written by
Anthony Pereyra <email@example.com>
WILHELM SCREAM: Heard when Thrax (after kidnapping Leah) hijacks a vehicle and throws out the driver. See more »
When Osmosis comes back from "The Zit" he greets Leah by saying "Brandy- oh I mean Leah". Brandy Norwood was the voice of Leah. The error was left in because it was acted so well and was funny. See more »
Hey, partner, what you got there?
Oh, these? These are polluted oysters. Well, they WERE polluted. I replanted them in six weeks ago. That's how long the state says you gotta do it for. And every time the tide came in, it flushed all the bad stuff out.
Can you eat 'em?
Well, if my hypotenuse is correct...
sure. Y-y-yeah, definitely.
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The Warner Brothers logo comes up looking like a germ-like substance with tentacles (with a blue tint) matching the "feel" of the movie, and is static instead of the modern 3D animated sequence. See more »
As an aesthete, this movie goes against everything I stand for, but I found it nonetheless very entertaining. It was like a peculiar yet satisfying mix between the Incredible Journey, Toy Story, and Lethal Weapon or Rush Hour (the whole loose-cannon, loner cop with a new partner bit).
I found the idea rather original: the human body is like a body of government, the cop is a white blood cell, the "president" was the cell whose will was that of the man (Bill Murray), the villain is a virus who hangs out in seedy areas of the body with shady characters, the bladder is a sort of train station/airport... clever stuff.
I did have issues with the "What a zit- I mean, what is it?" part, though: it landed on her lip! Wrong! I could have gone the rest of my life without seeing that. Molly Shannon is quite a sport. 7/10
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