The divine Shadow needs to periodically renew himself. The latest reincarnation is flawed and a series of events unfold that cause the destruction of the Shadows power and for a group of accidental rebels to steal the most powerful weapon in the two Universes, the starship Lexx.
As things settle down on the Lexx, the crew realizes Kai needs a constant supply of proto-blood to continue to function in the real world. Stanley and the others undertake a desperate mission to Kai's wrecked home world in search of a way to extend Kai's existence.
Lexx and the crew are running out of food resources. Desperate they visit what appears to be a garbage planet, but quickly become separated and under go a series of individual adventures in a culture thats basically cannibalistic.
The cleansing of the Cluster is complete and the birth of the Giga Shadow is progressing. These events are unknown to the crew of Lexx when they decide to journey to the Cluster for one last attempt to get the proto-blood Kai needs to continue his existence.