Begins with the same opening sequence as the series, except that the Professor accidentally adds a can of whoopass rather than Chemical X. The Whoopass Girls fight the Amoeba Boys, get stuck to them, and have to fly them into the sun to beat them.
In "Monkey See, Doggie Do", Mojo Jojo swipes some cursed artifacts from the Townsville Museum and using them, turns all of the people of Townsville and then the whole world into dogs. In "Mommy Fearest", the Professor falls for a mysterious woman who grounds the girls and bans them from staying up late to save the day. But it turns out that she is one of their many antagonists, Sedusa.
"Octi-Evil" Him is out to break up the Powerpuff Girls, and uses Bubbles sweetness to do it via Bubbles' stuffed octopus "Octi." But he is in for a big surprise when the Powerpuff Girls end up being stronger than they appear.
In "Boogie Frights", the Boogie Man comes up with a plan to forever keep out light in order to operate freely, but the Powerpuff Girls are on the job in a jiffy. In "Abracadaver", a long-dead resident magician, Al Lusion, comes back to life as a zombie, and the girls have some difficulty in trying to stop him.
"Major Competition" The Powerpuff Girl's place as crime fighters is taken when Major Man comes to town. The PPGs eventually figure out that Major Man is actually faking disasters just so he can "save the day."
In "Paste Makes Waste", one of the Pokey Oaks Kindergarten students has a bad habit of eating glue and Buttercup just can't resist picking on him for this. But when he accidentally eats some radioactive glue and turns into a giant glue monster, it's up to Buttercup to apologize for her behavior toward him to reverse the process. In "Ice Sore", during an intense heat wave, Blossom develops a new superpower, one that makes her sisters jealous, but her schoolmates popular with her: ice breath.
"Cat Man Do" The Girls save an innocent little Kitty from the clutches of an evil villain. Eventually they learn that Kitty is the true villain when he hypnotizes the Professor in an evil plot to take over the world.
In "Just Another Manic Mojo", Mojo Jojo's morning routine is disrupted by the Powerpuff Girls when their ball that they are playing with ends up in his lair. Mojo then uses this opportunity to try and eliminate his nemeses for good. In "Mime for a Change", Rainbow the Clown is accidentally transformed by bleach into an evil mime who can eliminate color and sound.