Angelina Jolie avoided any communication with Winona Ryder when making this movie claiming that if she saw anything human about Winona Ryder, she wouldn't have been able to act out the sociopath character of Lisa Rowe as effectively.
Lisa Rowe recites a poem by Dorothy Parker called "Resume": "Razors pain you; Rivers are damp; Acids stain you; And drugs cause cramp. Guns aren't lawful; Nooses give; Gas smells awful; You might as well live."
Winona Ryder's first lines in this movie are: "Have you ever confused a dream with life? Or stolen something when you have the cash?". Ironically, two years later, Winona was arrested for stealing bags in a department store.
Five actresses from the film had guests stints on "Grey's Anatomy" (2005): Clea Duvall, Elizabeth Moss, Jillian Armenante, Mary Kay Place, and KaDee Strickland appeared in it's spinoff, "Private Practise " (2007).