Pinky (series star ROB PAULSEN) and The Brain barter with an alien for advanced technology. But, the trading stalls when Elmyra mistakes the creature for a furry "bunny." DAVID PAYMER guest stars as the voice of Shad Equipo When Elmyra has a chance to win a portable laboratory at a science fair, Brain helps her by creating a model volcano. In the process, he discovers the secret of cold fusion! Now, he and Pinky must protect his discovery from sabotage by Rudy and certain unknown foes. JOHN VERNON returns as the voice of Principal Cheevers.
In order to obtain all the world's money, Brain must reprogram a satellite orbiting the Earth. Luckily, NASA is offering the opportunity for one child to go on the next space shuttle mission. Pinky and The Brain have the enormous task of teaching Elmyra about the solar system in order for her to win the trip. ED BEGLEY, JR. guest stars as the voice of Lloyd Oldtire. A vicious cat prevents Pinky and The Brain from carrying out their world domination plans. To make the cat more obedient like a dog, Brain concocts a DNA cocktail, but the cat's personality is altered in a...
The two mice pose as reporters in an attempt to make Elmyra popular. According to The Brain's theory, being popular should give her more friends--giving Pinky and The Brain more time to take over the planet. While telling a bedtime tale to Elmyra, The Brain adds his own unique alterations to the Cinderella story. In his version, The Brain is Cranky Mouseykins, who along with his assistant, Wee Willie Pinky, schemes to attire Cinder-Elmyra in his newest invention: leather shoes. Once the citizens of the kingdom see the ingenious footwear, they shall be freed from ...
Pinky and The Brain build a clubhouse where children can gather without being hassled by adults. The Brain desires to use their unhappiness with society as a launching point for a revolution. But Elmyra and the kids have other plans. Rudy inadvertently alerts a mysterious group called The Circle that is pursuing Pinky and The Brain. Soon, an agent of The Circle, Wally, purses the two mice. A subtle trap begins to close around Pinky and The Brain!
In a parody of Frank Capra's classic holiday film, "It's A Wonderful Life," The Brain dreams that he is back at Acme Labs. He soon learns what existence would be like if Elmyra replaced Pinky. Elmyra tells the story of how she flew to France on a giant robot named Roberto, who then transforms all the cheese into annoying American tourists.
The Brain invents a powerful scent that draws people to whoever wears it. But Elmyra inadvertently takes the scent to her school dance. The Brain must now infiltrate the event in his Patty Ann suit and retrieve the concoction. Pinky becomes enamored with the vision of a perfect life displayed by 1950s television comedies. After Elmyra buys Pinky a 1950s-style dollhouse, The Brain is slowly drawn into Pinky's fantasy world.
In this story told in poetic stanzas, Pinky and The Brain attempt to survive a typical day with Elmyra. When Rudy steals their Solar Ray, Pinky and The Brain must get it back. To do so, they must infiltrate Rudy's room, home to his ravenous anaconda.
Pinky and The Brain become Elmyra's campaign managers after she is nominated for class president. However, politics proves tricky, as they must manipulate Rudy Mookich into opposing Elmyra's opponents. After the annoying theme song from a children's amusement park ride is ingrained in their minds, Pinky and The Brain decide to alter the tune for their purposes. But in order to do so, they must negotiate the world's most chaotic theme park, Duckyland. ANDREA MARTIN guest stars as the voice of Ms. Entebbe.
Elmyra takes Pinky and The Brain and several other pets to the veterinarian's office. When the doctor wants to publicize her bizarre cat/dog, Pussy Wussy, the mice must act to prevent discovery by The Circle. T'KEYAH CRYSTAL KEYMAH guest stars as the voice of Nurse Gland; FRED WILLARD guest stars as the voice of Doctor Glen Tarantella and DAVID PAYMER returns as the voice of Shad Equipo. Pinky and The Brain broadcast their world domination plans on a public access TV station. However, when network executives accidentally see the show, they decide to air it nationally....
Pinky and The Brain create a black hole inside a jar and plan to sell the creation. But because of Elmyra, events soon spin wildly out of control. Pinky and The Brain plan to use the Patty Ann suit to try out for the Meat Queen contest. They win, but are forced to contend with Vanity's (recurring guest star voice talent JANE WIEDLIN) wrath and Elmyra's jealousy. TOWNSEND COLEMAN guest stars as the voice of Claude Gristle.
After learning that Rudy won't attend Vanity's (recurring guest star voice talent JANE WIEDLIN) big party, Elmyra begins sobbing uncontrollably. To stop her crying, Pinky and The Brain use the Patty Ann suit to lure Rudy to the event. Pinky and The Brain attempt to win public support by faking crimes and having The Brain, in the guise of crimefighting hero Braino, foil them. However, their plans backfire when Elmyra begins to gain fame as crimefighting hero Underwear Head. MICHAEL McKEAN guest stars as the voices of the Grocer, Robber and Policeman.