Debbie Reynolds talks about her life, tells the story of how her rib was broken by Roseanne, and sings a medley. Dominick Dunne talks about the Monica Lewinsky scandal. Roseanne interviews Crystal Lynne Pickett, the best friend of a fictional serial killer.
Roseanne banters with Kirstie Alley and plays a game of "Roseanne or Kirstie?" with the audience. A mother of three who adopted five siblings is crowned "Domestic Goddess." Kelly Price performs an original rendition of her song "Soul of a Woman," dedicated to the recently-crowned Domestic Goddess.
Roseanne talks with Lily Tomlin, who does her Edith Ann character, then she calls Cher in an attempt to retrieve a dog she claimed Cher swindled from her. Later Roseanne and Lily chat with former Texas governor Ann Richards.
Kathy Griffin discusses being in the tabloids. White supermodel Uta Sven discusses the horror of having reverse-Michael Jackson disease. Roseanne has a candid discussion with a group of teens about being young in the '90s.
Dame Edna banters about her daughter, celebrities, a line of beauty products and she prepares kangaroo stew. The inaugural installment of "3 Great Gals" features a trio of waitresses. A frumpy teacher gets a makeover.
Patti LaBelle discusses her penchant for pumps, friendship with the Clintons, she sings and goes shoe shopping with Roseanne. John Waters chats about his films, teaching film appreciation to inmates, and Roseanne gives him a Rorschach test.
Jennifer Tilly reads a scene from "Bride of Chucky" with Roseanne; Roseanne gets a candid interview from the Reverend Al Sharpton. Jennifer, Roseanne and Al appear in a skit with a bunch of male underwear models.
Eddie Izzard discusses transvestism and the Clinton sex scandal. Roseanne talks to Jim Bishop, a man who built a castle in Colorado. Tori Amos performs, discusses a drug-induced vision quest and talks to a group of victims from RAINN, the Rape, Abuse & Incest National Network, which she founded.
Kristen Johnston sets the record straight on tabloid reports that claimed she was about to be fired over her weight issues. Eccentric talk show host Virginia Graham gossips about her career. Emeril prepares a gourmet meal in 6 minutes.
Loretta Lynn discusses her career, inspiration for songs, being married and starting a family at 13, and she sings. Caroline Rhea talks about portraying a witch and Drew Carrey's girlfriend, and her unusual plane rides with celebrities.
The theme is sex with "Baywatch" beauty and Playboy Playmate Traci Bingham, Dr. Drew and Adam Carolla from "Loveline," author Anka Radakovich and a group of doctors who appeared in a famous Jockey Underwear ad.
Grace Slick discusses slipping LSD into the President's tea, sleeping with Jim Morrison, and she draws a sketch of Roseanne. Montego Bay Mama plugs her ranch, where female visitors are pleasured by virile young studs. Author Lauren Slater discusses her book "Prozac Diary."
Montel Williams discusses his legal battles and reveals how Roseanne's appearance on his talk show helped change the lives of a family of runaways. Phoebe Snow discusses her opera training, Matthew Shepard's death and prejudices she's faced, the strength she gained from her disabled daughter and reveals that she's clueless to her ethnic background. Snow performs "Poetry Man" and duets "Right to the End" with Michael McDonald.
Janeane Garofalo discusses her appearance, her friendship with Ben Stiller and working on indie films. Ice-T discusses his rough childhood, stint in the military and how he got going in the music business. Fashion designer Luscious Cleavage holds a Hoochie Mama Fashion Show.
Charlton Heston discusses starring in films as historical figures, the Clinton/Lewinsky scandal (which he equates to "The Wizard of Oz"), being a conservative in Hollywood, marching with Martin Luther King, his 54 year marriage and working with the NRA. Roseanne talks to Jody Pendarvis, a South Carolina man who constructed a "U.F.O. welcome center" in his front yard. Author Ellen Ladowsky gives advice on "How to Dump a Guy."
Chi McBride discusses the controversy surrounding his series "The Secret Diary of Desmond Pfeiffer" (which was canceled a few days later). Crystal Lynn Pickett returns to discuss why she's attracted to violent killers. Brian McKnight stops by to sing, discuss songwriting and influences, and take a shower with Roseanne.
Larry King discusses fatherhood at age 64, kissing Marlon Brando, why he wears suspenders and he's joined by Rabbi Irwin Katsof to discuss prayer and the book they co-authored. Roseanne brings three nuns on for her "Three Great Gals" segment -- a skydiver, a triathlete and a baseball enthusiast. Sir George Martin discusses his career working with the Beatles, and his latest release, "In My Life." Robin Williams, Jim Carrey and Céline Dion appear in clips recording songs for Martin's album.
Kathy Najimy discusses weight loss, her wedding and her love of skydiving. Billy Connolly discusses his looks, the British Royal Family and the headless dog who haunts his castle. Sidney Sheldon discusses his writing process and the creation of "The Patty Duke Show," "I Dream of Jeannie" and "Hart to Hart."
Penny Marshall discusses "Laverne & Shirley" and how she began her directorial career, and she shows off the wounded animal figurines she collects. Chris Isaak sings, discusses his bad dating luck, filming in Utah and surfing with killer whales. Gloria Steinem discusses her early life and appears on a "Dating Game"-like segment with eligible bachelors Chris Isaak and Mr. Blackwell.
Stephen Baldwin talks about his life, shows off his tattoos and does a striptease, flaunts his muscle car and plugs "One Tough Cop." Shawn and Marlon Wayans pose as security guards for a skit, talk about growing up poor and their relationship with Mike Tyson. Roseanne has chef (and former audience member) Willie Mae Wright prepare chicken.
Tammy Faye Bakker discusses why she wears makeup and surviving colon cancer, she plays the organ and duets "Old-Time Religion" with Roseanne. Chastity Bono discusses growing up with famous parents, coming out of the closet and the death of her father. Blues Traveler perform several songs, including the theme song for Roseanne's sitcom.