When Neal first sees his birthday gift, a red BMW convertible, the music wanders to the same few notes as in Back to the Future (also written by Bob Gale) when Marty opens the garage to see his new truck.
The character of O.W. Grant is a compilation of many different trickster figures in world mythologies. It is stated that he is half-leprechaun, which is shown in his red hair. Also, the monkey pipe is a reference to the Monkey figure of Eastern mythologies. The pipe's smoke can also be interpreted as a reference to Djinni.
When Neal and O.W. Grant are approaching interstate 60, O.W. says, "There's a signpost up ahead." This is a famous line from the beginning of every episode of Twilight Zone.
The number of the building where Neal has his appointment with Ray for the delivery is 555, an obvious reference to the fictional exchange for phone numbers in various movies. ("555" is reserved for phone company testing purposes, and no actual numbers exist using it in any area code.)
In Neal's room, a "X-Men" comic book featuring Cyclops on the cover can be seen. James Marsden (Neal) played Cyclops in X-Men, and would play the character again in its sequels.
There is no interstate highway number 60 in the The Dwight D. Eisenhower National System of Interstate and Defense Highways in the United States. If there were, its eastern end would have to be north of Raleigh NC (Interstate 40) south of Richmond VA (Interstate 64). Its western end would have to be south of Monroe UT (Interstate 79) and north of Barstow CA (Interstate 40).
According to Kurt Russell on the audio commentary on Big Trouble in Little China, he said that he shot one day on this movie and it was the most dialogue he had since making "Big Trouble".
When the movie starts and the two guys are discussing mythological wish-granters, there is a small sign on the bar wall that says "I'd rather be driving a MW." The 'MW' is from the 'BMW' logo, with the 'B' missing. Later, when Neal (James Marsden) is driving his new car, the logo has the 'MW' missing.